دورية
Anti-Endothelial Cell Autoantibodies and Soluble Markers of Endothelial Cell Dysfunction in Systemic Lupus Erythematosus
| العنوان: | Anti-Endothelial Cell Autoantibodies and Soluble Markers of Endothelial Cell Dysfunction in Systemic Lupus Erythematosus |
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| المؤلفون: | Constans, Joel, Dupuy, Remy, Blann, Andrew, Resplandy, Francois, Seigneur, Martine, Renard, Martine, Longy-Boursier, Maïte, Schaeverbeke, Thierry, Guérin, Viviane, Boisseau, Michel, Conri, Claude |
| المصدر: | Journal of Rheumatology; 09/1/2003, Vol. 30 Issue: 9 p1963-19661966, 19660004p |
| مستخلص: | OBJECTIVE: To determine if anti-endothelial cell antibodies (AECA) and plasma markers of endothelial cell function are related to disease severity in systemic lupus erythematosus (SLE). METHODS: We measured AECA by human umbilical vein endothelial cell binding, endothelial markers von Willebrand factor, soluble thrombomodulin, and soluble E-selectin by ELISA, and disease severity by SLEDAI and SLICC/ACR in 35 patients with SLE. RESULTS: Despite high levels of IgG AECA (p = 0.001) and von Willebrand factor (p = 0.0007) compared to 21 healthy controls, we found a positive correlation only between IgG AECA and the SLEDAI index (r = 0.393, p = 0.021). CONCLUSION: IgG AECA seem to be related to disease activity in SLE, possibly in a pathogenic role. Conversely, plasma markers of endothelial cell damage seem to be an epiphenomenon and may simply be related to excess inflammation. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 0315162X 14992752 |
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