دورية
Immunocytologic detection of isolated tumor cells in bone marrow of patients with squamous cell carcinomas of the head and neck region
| العنوان: | Immunocytologic detection of isolated tumor cells in bone marrow of patients with squamous cell carcinomas of the head and neck region |
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| المؤلفون: | Gath, H.J., Heissler, E., Hell, B., Bier, J., Riethmuller, G., Pantel, K. |
| المصدر: | International Journal of Oral & Maxillofacial Surgery; October 1995, Vol. 24 Issue: 5 p351-355, 5p |
| مستخلص: | The well-documented specificity of anticytokeratin monoclonal antibodies for detection of epithelial micrometastatic cancer cells in bone marrow as a prognostic indicator inspired us to apply this approach to patients with squamous cell carcinomas (SSC) of the head and neck region. The sensitivity of the broad-spectrum anticytokeratin monoclonal antibody (mAb) A45-B/B3 used for tumor cell detection was demonstrated by immunostaining of cryostat sections from the respective primary tumors. Analysis of 31 patients with SSC revealed A45-B/B3-positive cells in 10 cases (32.3%) at frequencies of 1-207 per 1x10^6 mononuclear cells. Most specimens displayed isolated tumor cells, while cell clusters were found in only two cases (6.5%). The present data suggest that hematogenous dissemination of cancer cells is more frequent than expected from clinicopathologic staging of patients with SSC of the head and neck region. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 09015027 13990020 |
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| DOI: | 10.1016/S0901-5027(05)80490-4 |