Effect of Sida corymbosa leaf extract on serum uric acid, urea and creatinine levels of alloxan-induced diabetic albino wistar rats
| العنوان: | Effect of Sida corymbosa leaf extract on serum uric acid, urea and creatinine levels of alloxan-induced diabetic albino wistar rats |
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| المؤلفون: | Ezeugwunne, IP, Eriugo, RC, Ogbodo, EC, Oguaka, VN, Analike, RA, Madukwe, DUP, Okwara, EC, Onyegbule, OA, Ezego, AI, Okeke, KU |
| المصدر: | International Journal of Basic, Applied and Innovative Research; Vol 6, No 2 (2017); 51-57 |
| بيانات النشر: | International Journal of Basic, Applied and Innovative Research, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Sida corymbosa, Kidney, Urea, Uric Acid, Creatinine |
| الوصف: | This study was designed to investigate the effect of Sida corymbosa (SC) leaf extract on serum uric acid, urea and creatinine levels in alloxan induced diabetic albino wistar rats. A total of 30 albino wistar rats each weighing 100g were assembled and divided into three groups (A-C) consisting of 10 rats in each group. Group A received SC treatment, B did not receive SC treatment, while group C served as the control group. 400mg/kg of aqueous extract of SC leaf was administered orally to the rats in group A but not in group B, while group C received only water for 7 days. Blood samples were collected into plain containers for estimation of serum uric acid, urea and creatinine. Serum uric acid, urea and creatinine were analyzed using Uricase, Urease-Berthlot and Jaffe Slot Alkaline picrate methods respectively. Results showed a significant increase in the mean serum levels of uric acid, urea and creatinine after SC treatment, when compared to the pre- treatment status. Similarly, there was a significant decrease in the mean weight of the rats after SC administration. Therefore, SC may have potential harmful effect on the kidney.Keywords: Sida corymbosa, Kidney, Urea, Uric Acid, Creatinine. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2315-5388 2384-681X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=78975075580c::5d0d734e8c597f4fc444175cfc38d9db https://www.ajol.info/index.php/ijbair/article/view/174921 |
| رقم الأكسشن: | edsair.78975075580c..5d0d734e8c597f4fc444175cfc38d9db |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23155388 2384681X |
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