Isolation of the New Antiplasmodial Butanolide, Malleastrumolide A, from Malleastrum sp (Meliaceae) from Madagascar
| العنوان: | Isolation of the New Antiplasmodial Butanolide, Malleastrumolide A, from Malleastrum sp (Meliaceae) from Madagascar |
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| المؤلفون: | Du Y, Abedi A, Valenciano A, Fernandez-Murga M, Cassera M, Rasamison V, Applequist W, Miller J, Kingston D |
| المصدر: | CHEMISTRY & BIODIVERSITY r-FISABIO. Repositorio Institucional de Producción Científica instname |
| بيانات النشر: | Wiley-Blackwell, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Butanolide, Madagascar, Malleastrum, Antiplasmodial activity, Meliaceae |
| الوصف: | An extract of Malleastrum sp. (Meliaceae) collected in Madagascar by the Madagascar International Cooperative Biodiversity Group was found to have antimalarial activity, with an IC50 value between 2.5 and 5gml(-1). After purification by liquid-liquid partition, chromatography on a Diaion open column, C18SPE and C-18 reversed phase HPLC, the new butanolide, malleastrumolide A, was isolated. The structure of malleastrumolide A was determined by mass spectrometry, NMR, and ECD. The double bond position was determined by cross-metathesis and mass spectrometry. The compound has antiproliferative activity against the A2780 ovarian cancer cell line with an IC50 value of 17.4m and antiplasmodial activity against the drug-resistant Dd2 strain of Plasmodium falciparum with an IC50 value of 2.74m. |
| تدمد: | 1612-1872 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::2e19e087fcac491d45554531f56d29cc https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=13080 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.RECOLECTA.....2e19e087fcac491d45554531f56d29cc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16121872 |
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