Retinoblastoma seeds: impact on American Joint Committee on Cancer clinical staging
| العنوان: | Retinoblastoma seeds: impact on American Joint Committee on Cancer clinical staging |
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| المؤلفون: | Tomar AS, Finger PT, Gallie B, Kivelä T, Mallipatna A, Zhang C, Zhao J, Wilson M, Brennan R, Burges M, Kim J, Berry JL, Jubran R, Khetan V, Ganeshan S, Yarovoy A, Yarovaya V, Kotova E, Volodin D, Yousef Y, Nummi K, Ushakova TL, Yugay OV, Polyakov VG, Ramirez-Ortiz MA, Esparza-Aguiar E, Chantada GL, Schaiquevich P, Fandiño AC, Yam JC, Lau WW, Lam CP, Sharwood P, Moorthy S, Long QB, Essuman VA, Renner LA, Semenova E, Catala J, Correa Llano M, Carreras E, American Joint Committee on Cancer Ophthalmic Oncology Task Force, American Joint Committee on Cancer Ophthalmic Oncology Task |
| المصدر: | BRITISH JOURNAL OF OPHTHALMOLOGY r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname |
| بيانات النشر: | BMJ Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | vitreous, neoplasia, retina, genetic structures, pathology, eye diseases |
| الوصف: | AIM: To investigate whether the American Joint Committee on Cancer (AJCC) clinical category cT2b needs to be subclassified by the type and distribution of retinoblastoma (RB) seeding. METHODS: Multicentre, international registry-based data were collected from RB centres enrolled between January 2001 and December 2013. 1054 RB eyes with vitreous or subretinal seeds from 18 ophthalmic oncology centres, in 13 countries within six continents were analysed. Local treatment failure was defined as the use of secondary enucleation or external beam radiation therapy (EBRT) and was estimated with the Kaplan-Meier method. RESULTS: Clinical category cT2b included 1054 eyes. Median age at presentation was 16.0 months. Of these, 428 (40.6%) eyes were salvaged, and 430 (40.8%) were treated with primary and 196 (18.6%) with secondary enucleation. Of the 592 eyes that had complete data for globe salvage analysis, the distribution of seeds was focal in 143 (24.2%) and diffuse in 449 (75.8%). The 5-year Kaplan-Meier cumulative globe-salvage (without EBRT) was 78% and 49% for eyes with focal and diffuse RB seeding, respectively. Cox proportional hazards regression analysis confirmed a higher local treatment failure risk with diffuse seeds as compared with focal seeds (hazard rate: 2.8; p |
| تدمد: | 0007-1161 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::41e0e384ddb02d91b422f3971facaa8d http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19979 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.RECOLECTA.....41e0e384ddb02d91b422f3971facaa8d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00071161 |
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