Elevated Extracellular Free-Water in a Multicentric First-Episode Psychosis Sample, Decrease During the First 2 Years of Illness
| العنوان: | Elevated Extracellular Free-Water in a Multicentric First-Episode Psychosis Sample, Decrease During the First 2 Years of Illness |
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| المؤلفون: | Berge D, Mane A, Lesh T, Bioque M, Barcones F, Gonzalez-Pinto A, Parellada M, Vieta E, Castro-Fornieles J, Rodriguez-Jimenez R, Garcia-Portilla M, Usall J, Carter C, Cabrera B, Bernardo M, Janssen J, PEPs group (collaborators) |
| المصدر: | SCHIZOPHRENIA BULLETIN r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname |
| بيانات النشر: | OXFORD UNIV PRESS, 2020. |
| سنة النشر: | 2020 |
| الوصف: | Recent diffusion imaging studies using free-water (FW) elimination have shown increased FW in gray matter (GM) and white matter (WM) in first-episode psychosis (FEP) and lower corrected fractional anisotropy (FAt) in WM in chronic schizophrenia. However, little is known about the longitudinal stability and clinical significance of these findings. To determine tissue-specific FW and FAt abnormalities in FEP, as part of a multicenter Spanish study, 132 FEP and 108 healthy controls (HC) were clinically characterized and underwent structural and diffusion-weighted MRI scanning. FEP subjects were classified as schizophrenia spectrum disorder (SSD) or non-SSD. Of these subjects, 45 FEP and 41 HC were longitudinally assessed and rescanned after 2 years. FA and FW tissue-specific measurements were cross-sectional and longitudinally compared between groups using voxel-wise analyses in the skeletonized WM and vertex-wise analyses in the GM surface. SSD and non-SSD subjects showed (a) higher baseline FW in temporal regions and in whole GM average (P.adj(SSD vs HC) = .003, P.adj(Non-SSD vs HC) = .040) and (b) lower baseline FAt in several WM tracts. SSD, but not non-SSD, showed (a) higher FW in several WM tracts and in whole WM (P.adj(SSD vs HC)= .049) and (b) a significant FW decrease over time in temporal cortical regions and in whole GM average (P.adj = .011). Increased extracellular FW in the brain is a reliable finding in FEP, and in SSD appears to decrease over the early course of the illness. FAt abnormalities are stable during the first years of psychosis. © The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.All rights reserved. For permissions, please email: journals.permissions@oup.com. |
| تدمد: | 0586-7614 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::ebfd6159dadbac1d95b0bf906a6108e7 https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4463 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.RECOLECTA.....ebfd6159dadbac1d95b0bf906a6108e7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 05867614 |
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