Circulating miRNAs in Small Extracellular Vesicles Secreted by a Human Melanoma Xenograft in Mouse Brains
| العنوان: | Circulating miRNAs in Small Extracellular Vesicles Secreted by a Human Melanoma Xenograft in Mouse Brains |
|---|---|
| المؤلفون: | Loredana Guglielmi 1, Marta Nardella 2, Carla Musa 3, Ingrid Cifola 1, Manuela Porru 4, Beatrice Cardinali 3, Ilaria Iannetti 3, Chiara Di Pietro 3, Giulia Bolasco 5, Valentina Palmieri 6, 7, Laura Vilardo 1, Nicolò Panini 8, Fabrizio Bonaventura 3, Massimiliano Papi 6, Ferdinando Scavizzi 3, Marcello Raspa 3, Carlo Leonetti 4, Germana Falcone 3, Armando Felsani 9, and Igea D'Agnano 1 |
| المصدر: | Cancers (Basel) (2020). info:cnr-pdr/source/autori:Loredana Guglielmi 1,+, Marta Nardella 2,+, Carla Musa 3,+, Ingrid Cifola 1,+, Manuela Porru 4, Beatrice Cardinali 3, Ilaria Iannetti 3, Chiara Di Pietro 3, Giulia Bolasco 5, Valentina Palmieri 6,7, Laura Vilardo 1, Nicolò Panini 8, Fabrizio Bonaventura 3, Massimiliano Papi 6,7, Ferdinando Scavizzi 3, Marcello Raspa 3, Carlo Leonetti 4,?, Germana Falcone 3,?, Armando Felsani 9,? and Igea D'Agnano 1,*,?/titolo:Circulating miRNAs in Small Extracellular Vesicles Secreted by a Human Melanoma Xenograft in Mouse Brains/doi:/rivista:Cancers (Basel)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| بيانات النشر: | MDPI, Basel, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | melanoma, circulating miRNAs, small extracellular vesicles |
| الوصف: | The identification of liquid biomarkers remains a major challenge to improve the diagnosis of melanoma patients with brain metastases. Circulating miRNAs packaged into tumorsecreted small extracellular vesicles (sEVs) contribute to tumor progression. To investigate the release of tumor-secreted miRNAs by brain metastasis, we developed a xenograft model where human metastatic melanoma cells were injected intracranially in nude mice. The comprehensive profiles of both free miRNAs and those packaged in sEVs secreted by the melanoma cells in the plasma demonstrated that most (80%) of the sEV-associated miRNAs were also present in serum EVs from a cohort of metastatic melanomas, included in a publicly available dataset. Remarkably, among them, we found three miRNAs (miR-224-5p, miR-130a-3p and miR-21-5p) in sEVs showing a trend of upregulation during melanoma progression. Our model is proven to be valuable for identifying miRNAs in EVs that are unequivocally secreted by melanoma cells in the brain and could be associated to disease progression |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=cnr_________::1fb15bb01db7349a35718b84ae406547 http://www.cnr.it/prodotto/i/424284 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.cnr...........1fb15bb01db7349a35718b84ae406547 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |