Fever without source as the first manifestation of SARS-CoV-2 infection in infants less than 90 days old
| العنوان: | Fever without source as the first manifestation of SARS-CoV-2 infection in infants less than 90 days old |
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| المؤلفون: | Blázquez-Gamero D, Epalza C, Cadenas JAA, Gero LC, Calvo C, Rodríguez-Molino P, Méndez M, Santos MDM, Fumadó Victoria, Guzmán MF, Soriano-Arandes A, Jiménez AB, Penin M, Cobo-Vazquez E, Pareja M, ZULEMA LOBATO SALINAS, Serna M, Delgado R, Moraleda C, Tagarro A |
| المصدر: | EUROPEAN JOURNAL OF PEDIATRICS r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu |
| بيانات النشر: | SPRINGER, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Coronavirus, SARS-CoV2, COVID-19, Infant, Serious bacterial infections, Fever without source |
| الوصف: | Fever without source (FWS) in infants is a frequent cause of consultation at the emergency department, and the emergence of SARS-CoV-2 could affect the approach to those infants. The aim of this study is to define the clinical characteristics and rates of bacterial coinfections of infants < 90 days with FWS as the first manifestation of SARS-CoV-2 infection. This is a cross-sectional study of infants under 90 days of age with FWS and positive SARS-CoV2 PCR in nasopharyngeal swab/aspirate, attended at the emergency departments of 49 Spanish hospitals (EPICO-AEP cohort) from March 1 to June 26, 2020. Three hundred and thirty-three children with COVID-19 were included in EPICO-AEP. A total of 67/336 (20%) were infants less than 90 days old, and 27/67(40%) presented with FWS. Blood cultures were performed in 24/27(89%) and were negative in all but one (4%) who presented a Streptococcus mitis bacteremia. Urine culture was performed in 26/27(97%) children and was negative in all, except in two (7%) patients. Lumbar puncture was performed in 6/27(22%) cases, with no growth of bacteria. Two children had bacterial coinfections: 1 had UTI and bacteremia, and 1 had UTI. C-reactive was protein over 20 mg/L in two children (one with bacterial coinfection), and procalcitonin was normal in all. One child was admitted to the pediatric intensive care unit because of apnea episodes. No patients died.Conclusion: FWS was frequent in infants under 90 days of age with SARS-CoV-2 infection. Standardized markers to rule out bacterial infections remain useful in this population, and the outcome is generally good. What is Known: • Fever without source (FWS) in infants is a common cause of consultation at the emergency department, and young infants have a higher risk of serious bacterial infections (SBI). • The emergence of the new coronavirus SARS-CoV-2 could affect the approach to young infants with FWS in the emergency department. management of those children is a challenge because information about bacterial coinfection and prognosis is scarce. What is New: • SARS-CoV-2 infection should be ruled out in young infants (< 90 days of age) with FWS in areas with community transmission. • Bacterial coinfection rarely coexists in those infants. • Inflammatory markers were not increased in children without bacterial coinfection. • Outcome is good in most patients. |
| تدمد: | 0340-6199 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::070e2b17ef0266b08e7bb68d72147dd5 http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19145 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..070e2b17ef0266b08e7bb68d72147dd5 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 03406199 |
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