Real life outcomes of patients aged >= 75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry
| العنوان: | Real life outcomes of patients aged >= 75 years old with acute promyelocytic leukemia: experience of the PETHEMA registry |
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| المؤلفون: | Salamero O, Mart?nez-Cuadr?n D, Sobas M, Benavente C, Vives S, De la Serna J, P?rez-Encinas M, Escoda L, Gil C, Brunet S, Ramos F, Esteve J, Amigo M, Krsnik I, Manso F, Arias J, Gonz?lez-Campos J, Serrano J, Oleksiuk J, Barrios M, Garc?a-Boyero R, Novo A, Sanz M, Montesinos P, Helbig G, Holowiecka A, Armatys A, Hawrylecka D, Golos A, Ejduk A, Majcherek M, Skret A, Czyzewska J, Grosicki S, Zarzycka E, Watek M, Piatkowska-Jakubas B, Holojda J, Pluta A, Podhorecka M, Gromek T, Guzicka E, Charlinski G, Paluszewska M, de Heredia J, Hern?ndez J, Rom?n A, de la Serna J, Negri S, Ray?n C, Fern?ndez-Calvo F, D?az-Mediavilla J, Tormo M, Olave M, Amutio E, Pedro C, Gorosquieta A, Viguria M, Zudaire M, Molero T, Sayas M, Guardia R, Rivas C, Esquembre C, Garc?a R, Alcal? A, L?pez J, Rubio V, Linares M, Ribera J, San Miguel J, Deb?n G, de la C?mara R, Molines A, Loureiro C, Allegue M, Amador L, Mart? J, Madero L, Lassaletta A, Cabezudo M, Garc?a-Larana J, Rojas R, Ortega F, Pe?arrubia M, Puente F, Lopez-Ibor B, Bergua J, Ib??ez J, S?nchez P, Font L, Guinea J, Montero A, Gonz?lez M, Mart?n G, Mart?nez J, Verdeguer A, Garc?a P, Conde E, Garc?a J, Capote F, Bueno J, Bastida P, Rubio A, Fuster J, Gonz?lez J, P?rez I, Molina J, Mateos M, Ardaiz M, Rodr?guez-Calvillo M, Poder?s C, Arn?n M, Duarte R, D?az-Morfa M, Mart?n-Chac?n E, Calvo-Villas J, Garc?a-Belmonte D, Hern?ndez-Maraver D, Miskiewicz W, PETHEMA Grp, PALG Grp |
| المصدر: | LEUKEMIA & LYMPHOMA r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica instname |
| بيانات النشر: | TAYLOR & FRANCIS LTD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | induction mortality in APL, APL real life outcomes, Elderly APL, APL prognostic factors, neoplasms |
| الوصف: | Acute promyelocytic leukemia is infrequent among patients aged >= 75 years old, a population that is rarely eligible for clinical protocols. This study aims to analyze the treatment strategies and clinical outcomes of very old APL patients reported to the international PETHEMA registry. Between 1997 and 2017, among 2501 APL cases registered 120 were >= 75 years old. Treatment approaches were: AIDA regimen, 79 patients; ATRA alone, 23; 16, supportive care (SC) and 2, other strategies. Patients treated with AIDA were younger, had better ECOG and lower leukocytes. Complete remission (CR) was achieved in 65% of AIDA-group vs. 45% in the ATRA-group, being infections followed by bleeding the most frequent causes of induction death. Patients in CR after AIDA showed 3-year DFS of 73%. Our real-life series of very old APL patients provides a reference basis for future treatment strategies aiming to improve clinical outcomes in this challenging population. |
| تدمد: | 1042-8194 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::18d09b23d62783b6990f1f5f2c18ad0e https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=7288 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..18d09b23d62783b6990f1f5f2c18ad0e |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 10428194 |
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