Estrogen withdrawal and replacement differentially target liver and adipose tissues in 1 female mice fed a high-fat high-sucrose diet. Impact of a chronic exposure to a low-dose 2 pollutant mixture. 3 the French 'Ministère de l'Education
| العنوان: | Estrogen withdrawal and replacement differentially target liver and adipose tissues in 1 female mice fed a high-fat high-sucrose diet. Impact of a chronic exposure to a low-dose 2 pollutant mixture. 3 the French 'Ministère de l'Education |
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| المؤلفون: | JULIEN, Benoit, Pinteur, Claudie, Vega, Nathalie, Vidal, Hubert, Naville, Danielle, Le Magueresse-Battistoni, Brigitte |
| المساهمون: | Le Magueresse-Battistoni, Brigitte, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), This research project was supported by INSERM to InsermU1060. Benoit 19 Julien is supported by a research fellowship from the French 'Ministère de l’Education 20 Nationale, de l’Enseignement Supérieur et de la Recherche'., Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL) |
| المصدر: | The Journal of Nutritional Biochemistry The Journal of Nutritional Biochemistry, Elsevier, 2019, 72, pp.108211. ⟨10.1016/j.jnutbio.2019.07.002⟩ The Journal of Nutritional Biochemistry, 2019, 72, pp.108211. ⟨10.1016/j.jnutbio.2019.07.002⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Ovariectomy, Metabolic disorders, Estradiol replacement, High-fat high-sucrose diet, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Mixture of pollutants |
| الوصف: | Claudie Pinteur and Nathalie Vega contributed equally.; International audience; Postmenopausal women may be at particular risk when exposed to chemicals especially endocrine disruptors because of hormonal deficit. To get more insight, ovariectomized C57Bl6/J mice fed a high-fat high-sucrose diet were chronically exposed from 5 to 20 weeks of age to a low-dose mixture of chemicals with one dioxin, one polychlorobiphenyl, one phthalate and bisphenol A. Part of the mice received as well E2 implants to explore the potential estrogenic dependency of the metabolic alterations. With this model, estrogen loss resulted in glucose but not lipid metabolism impairment, and E2 replacement normalized the enhanced body and fat pad weight, and the glucose intolerance and insulin resistance linked to ovariectomy. It also altered cholesterol metabolism in the liver concurrently with enhanced estrogen receptor Esr1 mRNA level. In addition, fat depots responded differently to estrogen withdrawal (e.g., selective mRNA enhancement of adipogenesis markers in subcutaneous and of inflammation in visceral fat pads) and replacement challenges. Importantly, the pollutant mixture impacted lipid deposition and mRNA expression of several genes related to lipid metabolism but not Esr1 in the liver. Adiponectin levels were altered as well. In addition, the mRNA abundance of the various estrogen receptors was regionally impacted in fat tissues. Besides, xenobiotic processing genes did not change in response to the pollutant mixture in the liver. The present findings bring new light on estrogen-dependent metabolic alterations with regards to situations of loss of estrogens as observed after menopause. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0955-2863 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::288ebb324f97243687d83b8280d044ba https://www.hal.inserm.fr/inserm-02302156 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..288ebb324f97243687d83b8280d044ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09552863 |
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