Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
| العنوان: | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants |
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| المؤلفون: | Dadaev, Tokhir, Saunders, Edward J., Newcombe, Paul J., Anokian, Ezequiel, Leongamornlert, Daniel A., Brook, Mark N., Cieza-Borrella, Clara, Mijuskovic, Martina, Wakerell, Sarah, Olama, Ali Amin Al, Schumacher, Fredrick R., Berndt, Sonja I., Benlloch, Sara, Ahmed, Mahbubl, Goh, Chee, Sheng, Xin, Zhang, Zhuo, Muir, Kenneth, Govindasami, Koveela, Lophatananon, Artitaya, Stevens, Victoria L., Gapstur, Susan M., Carter, Brian D., Tangen, Catherine M., Goodman, Phyllis, Thompson, Ian M., Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Clements, Judith, Horvath, Lisa, Tilley, Wayne, Risbridger, Gail, Gronberg, Henrik, Aly, Markus, Nordström, Tobias, Pharoah, Paul, Pashayan, Nora, Schleutker, Johanna, Tammela, Teuvo L.J., Sipeky, Csilla, Auvinen, Anssi, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, Hakansson, Niclas, West, Catharine, Dunning, Alison M., Burnet, Neil, Mucci, Lorelei, Giovannucci, Edward, Andriole, Gerald, Cussenot, Olivier, Cancel-Tassin, Géraldine, Koutros, Stella, Freeman, Laura E.Beane, Sorensen, Karina Dalsgaard, Orntoft, Torben Falck, Borre, Michael, Maehle, Lovise, Grindedal, Eli Marie, Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Travis, Ruth C., Key, Tim J., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Ingles, Sue Ann, Stern, Mariana C., Rosenstein, Barry, Kerns, Sarah, Ostrer, Harry, Lu, Yong Jie, Zhang, Hong Wei, Feng, Ninghan, Mao, Xueying, Guo, Xin, Wang, Guomin, Sun, Zan, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Fitzgerald, Liesel M., Kibel, Adam S., Drake, Bettina F., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Szulkin, Robert, Eklund, Martin, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Penney, Kathryn L., Stampfer, Meir, Park, Jong Y., Sellers, Thomas A., Lin, Hui Yi, Stanford, Janet L., Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Ostrander, Elaine A., Geybels, Milan S., Nordestgaard, Børge G., Nielsen, Sune F., Weisher, Maren, Bisbjerg, Rasmus, Røder, Martin Andreas, Iversen, Peter, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Maier, Christiane, Luedeke, Manuel, Schnoeller, Thomas, Kim, Jeri, Logothetis, Christopher J., John, Esther M., Teixeira, Manuel R., Paulo, Paula, Cardoso, Marta, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Razack, Azad, Lim, Jasmine, Teo, Soo Hwang, Lin, Daniel W., Newcomb, Lisa F., Lessel, Davor, Gamulin, Marija, Kulis, Tomislav, Kaneva, Radka, Usmani, Nawaid, Slavov, Chavdar, Mitev, Vanio, Parliament, Matthew, Singhal, Sandeep, Claessens, Frank, Joniau, Steven, Van Den Broeck, Thomas, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Roobol, Monique J., Jenster, Guido, Van Schaik, Ron H.N., Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, Xu, Jianfeng, Khaw, Kay Tee, Cannon-Albright, Lisa, Pandha, Hardev, Michael, Agnieszka, Kierzek, Andrzej, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., Lindstrom, Sara, Turman, Constance, Ma, Jing, Hunter, David J., Riboli, Elio, Siddiq, Afshan, Canzian, Federico, Kolonel, Laurence N., Le Marchand, Loic, Hoover, Robert N., Machiela, Mitchell J., Kraft, Peter, Cook, Margaret, Thwaites, Alison, Guy, Michelle, Whitmore, Ian, Morgan, Angela, Fisher, Cyril, Hazel, Steve, Livni, Naomi, Spurdle, Amanda, Srinivasan, Srilakshmi, Kedda, Mary Anne, Aitken, Joanne, Gardiner, Robert, Hayes, Vanessa, Butler, Lisa, Taylor, Renea, Yeadon, Trina, Eckert, Allison, Saunders, Pamela, Haynes, Anne Maree, Papargiris, Melissa, Kujala, Paula, Talala, Kirsi, Murtola, Teemu, Taari, Kimmo, Dearnaley, David, Barnett, Gill, Bentzen, Søren, Elliott, Rebecca, Ranu, Hardeep, Hicks, Belynda, Vogt, Aurelie, Hutchinson, Amy, Cox, Angela, Davis, Michael, Brown, Paul, George, Anne, Marsden, Gemma, Lane, Athene, Lewis, Sarah J., Berry, Clare, Kulkarni, Girish S., Toi, Ants, Evans, Andrew, Zlotta, Alexandre R., Van Der Kwast, Theodorus H., Imai, Takashi, Saito, Shiro, Marzec, Jacek, Cao, Guangwen, Lin, Ji, Ling, Jin, Li, Meiling, Zhao, Shan Chao, Ren, Guoping, Yu, Yongwei, Wu, Yudong, Wu, Ji, Zhou, Bo, Zhang, Yangling, Li, Jie, He, Weiyang, Guo, Jianming, Pedersen, John, Hopper, John L., Milne, Roger, Klim, Aleksandra, Carballo, Ana, Lobato-Busto, Ramón, Peleteiro, Paula, Calvo, Patricia, Aguado, Miguel, Ruiz-Dominguez, José Manuel, Cecchini, Lluís, Mengual, Lourdes, Alcaraz, Antonio, Bustamante, Mariona, Gracia-Lavedan, Esther, Dierssen-Sotos, Trinidad, Gomez-Acebo, Ines, Pow-Sang, Julio, Park, Hyun, Zachariah, Babu, Kluzniak, Wojciech, Kolb, Suzanne, Klarskov, Peter, Stegmaier, Christa, Vogel, Walther, Herkommer, Kathleen, Bohnert, Philipp, Maia, Sofia, Silva, Maria P., De Langhe, Sofie, Thierens, Hubert, Tan, Meng H., Ong, Aik T., Kastelan, Zeljko, Popov, Elenko, Kachakova, Darina, Mitkova, Atanaska, Vlahova, Aleksandrina, Dikov, Tihomir, Christova, Svetlana, Carracedo, Angel, Bangma, Christopher, Schroder, F. H., Cenee, Sylvie, Tretarre, Brigitte, Rebillard, Xavier, Mulot, Claire, Sanchez, Marie, Adolfsson, Jan, Stattin, Par, Johansson, Jan Erik, Cavalli-Bjoerkman, Carin, Karlsson, Ami, Broms, Michael, Wu, Huihai, Tillmans, Lori, Riska, Shaun, Freedman, Matthew, Wiklund, Fredrik, Chanock, Stephen, Henderson, Brian E., Easton, Douglas F., Haiman, Christopher A., Eeles, Rosalind A., Conti, David V., Kote-Jarai, Zsofia |
| المصدر: | Dadaev, T, Saunders, E J, Newcombe, P J, Anokian, E, Leongamornlert, D A, Brook, M N, Cieza-Borrella, C, Mijuskovic, M, Wakerell, S, Olama, A A A, Schumacher, F R, Berndt, S I, Benlloch, S, Ahmed, M, Goh, C, Sheng, X, Zhang, Z, Muir, K, Govindasami, K, Lophatananon, A, Stevens, V L, Gapstur, S M, Carter, B D, Tangen, C M, Goodman, P, Thompson, I M, Batra, J, Chambers, S, Moya, L, Clements, J, Horvath, L, Tilley, W, Risbridger, G, Gronberg, H, Aly, M, Nordström, T, Pharoah, P, Pashayan, N, Schleutker, J, Tammela, T L J, Sipeky, C, Auvinen, A, Albanes, D, Weinstein, S, Wolk, A, Hakansson, N, West, C, Dunning, A M, Burnet, N, Mucci, L, Giovannucci, E, Andriole, G, Cussenot, O, Cancel-Tassin, G, Koutros, S, Freeman, L E B, Sorensen, K D, Orntoft, T F, Borre, M, Maehle, L, Grindedal, E M, Neal, D E, Donovan, J L, Hamdy, F C, Martin, R M, Travis, R C, Key, T J, Hamilton, R J, Fleshner, N E, Finelli, A, Ingles, S A, Stern, M C, Rosenstein, B, Kerns, S, Ostrer, H, Lu, Y J, Zhang, H W, Feng, N, Mao, X, Guo, X, Wang, G, Sun, Z, Giles, G G, Southey, M C, MacInnis, R J, Fitzgerald, L M, Kibel, A S, Drake, B F, Vega, A, Gómez-Caamaño, A, Fachal, L, Szulkin, R, Eklund, M, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Penney, K L, Stampfer, M, Park, J Y, Sellers, T A, Lin, H Y, Stanford, J L, Cybulski, C, Wokolorczyk, D, Lubinski, J, Ostrander, E A, Geybels, M S, Nordestgaard, B G, Nielsen, S F, Weisher, M, Bisbjerg, R, Røder, M A, Iversen, P, Brenner, H, Cuk, K, Holleczek, B, Maier, C, Luedeke, M, Schnoeller, T, Kim, J, Logothetis, C J, John, E M, Teixeira, M R, Paulo, P, Cardoso, M, Neuhausen, S L, Steele, L, Ding, Y C, De Ruyck, K, De Meerleer, G, Ost, P, Razack, A, Lim, J, Teo, S H, Lin, D W, Newcomb, L F, Lessel, D, Gamulin, M, Kulis, T, Kaneva, R, Usmani, N, Slavov, C, Mitev, V, Parliament, M, Singhal, S, Claessens, F, Joniau, S, Van Den Broeck, T, Larkin, S, Townsend, P A, Aukim-Hastie, C, Gago-Dominguez, M, Castelao, J E, Martinez, M E, Roobol, M J, Jenster, G, Van Schaik, R H N, Menegaux, F, Truong, T, Koudou, Y A, Xu, J, Khaw, K T, Cannon-Albright, L, Pandha, H, Michael, A, Kierzek, A, Thibodeau, S N, McDonnell, S K, Schaid, D J, Lindstrom, S, Turman, C, Ma, J, Hunter, D J, Riboli, E, Siddiq, A, Canzian, F, Kolonel, L N, Le Marchand, L, Hoover, R N, Machiela, M J, Kraft, P, Cook, M, Thwaites, A, Guy, M, Whitmore, I, Morgan, A, Fisher, C, Hazel, S, Livni, N, Spurdle, A, Srinivasan, S, Kedda, M A, Aitken, J, Gardiner, R, Hayes, V, Butler, L, Taylor, R, Yeadon, T, Eckert, A, Saunders, P, Haynes, A M, Papargiris, M, Kujala, P, Talala, K, Murtola, T, Taari, K, Dearnaley, D, Barnett, G, Bentzen, S, Elliott, R, Ranu, H, Hicks, B, Vogt, A, Hutchinson, A, Cox, A, Davis, M, Brown, P, George, A, Marsden, G, Lane, A, Lewis, S J, Berry, C, Kulkarni, G S, Toi, A, Evans, A, Zlotta, A R, Van Der Kwast, T H, Imai, T, Saito, S, Marzec, J, Cao, G, Lin, J, Ling, J, Li, M, Zhao, S C, Ren, G, Yu, Y, Wu, Y, Wu, J, Zhou, B, Zhang, Y, Li, J, He, W, Guo, J, Pedersen, J, Hopper, J L, Milne, R, Klim, A, Carballo, A, Lobato-Busto, R, Peleteiro, P, Calvo, P, Aguado, M, Ruiz-Dominguez, J M, Cecchini, L, Mengual, L, Alcaraz, A, Bustamante, M, Gracia-Lavedan, E, Dierssen-Sotos, T, Gomez-Acebo, I, Pow-Sang, J, Park, H, Zachariah, B, Kluzniak, W, Kolb, S, Klarskov, P, Stegmaier, C, Vogel, W, Herkommer, K, Bohnert, P, Maia, S, Silva, M P, De Langhe, S, Thierens, H, Tan, M H, Ong, A T, Kastelan, Z, Popov, E, Kachakova, D, Mitkova, A, Vlahova, A, Dikov, T, Christova, S, Carracedo, A, Bangma, C, Schroder, F H, Cenee, S, Tretarre, B, Rebillard, X, Mulot, C, Sanchez, M, Adolfsson, J, Stattin, P, Johansson, J E, Cavalli-Bjoerkman, C, Karlsson, A, Broms, M, Wu, H, Tillmans, L, Riska, S, Freedman, M, Wiklund, F, Chanock, S, Henderson, B E, Easton, D F, Haiman, C A, Eeles, R A, Conti, D V & Kote-Jarai, Z 2018, ' Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants ', Nature Communications, vol. 9, no. 1, 2256 . https://doi.org/10.1038/s41467-018-04109-8 |
| بيانات النشر: | Nature Publishing Group, 2018. |
| سنة النشر: | 2018 |
| الوصف: | Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::29de179b88c5a5d43817d22edb744167 https://acuresearchbank.acu.edu.au/item/8x556/fine-mapping-of-prostate-cancer-susceptibility-loci-in-a-large-meta-analysis-identifies-candidate-causal-variants |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..29de179b88c5a5d43817d22edb744167 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |