Optical Coeherence Tomography: a Window to Multiple Sclerosis?
| العنوان: | Optical Coeherence Tomography: a Window to Multiple Sclerosis? |
|---|---|
| المؤلفون: | Proença, R, Cardigos, J, Costa, L, Vicente, A, Santos, A, Amado, D, Ferreira, J, Cunha, JP |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| بيانات النشر: | Sociedade Portuguesa de Oftalmologia, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | CHLC OFT, genetic structures, Estudos Retrospectivos, Esclerose Múltipla, sense organs, Tomografia de Coerência Óptica, eye diseases |
| الوصف: | Introduction: Multiple sclerosis (MS) is an inflammatory immune-mediated demyelinating disease that frequently affects the central nervous system. Approximately 20% of patients have optic neuritis has the first manifestation of the disease. Its frequency, heterogeneity and absence of definitive treatment make it a therapeutic and diagnostic challenge for both the patient and the clinician. Material and methods: Retrospective study of 133 eyes of 87 patients, 38 patients with MS (Group 1), 9 patients with isolated optic neuritis (Group 2) and 40 healthy patients (Group 3) from the Neurophthalmology Department of Centro Hospitalar de Lisboa Central from January 2013 to August 2015. Patients were characterized according to gender, age, years of follow-up, best corrected visual acuity, presence of other ocular disorders and episodes of optic neuritis. Patients with other ocular pathologies were excluded. Optical coherence tomography (OCT Spectralis, Heidelberg Engineering) of the macular region was done in all patients, followed by automatic segmentation of the retinal layer. Statistical tests were made to calculate statistically significant results between different groups. Results: Of the 87 patients evaluated, the mean age in Group 1 was 41.55 compared to 36.88 in Group 2 and 44.73 in the control group. Mean age of diagnosis for patients with MS was 33.73 years with a mean follow up of 8.01 years, whereas patients with isolated optic neuritis had a mean age of diagnosis of 34.33 years, with a mean follow-up of 2.88 years. Best corrected visual acuity ranged from 0.2 to 1.0 in Group 1 and 0.5 to 1.0 in Group 2. In patients with previous episodes of optic neuritis isolated or associated with multiple sclerosis we observed a statistically significant (p |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2c797ec5878971eb17ba2c41c781dadf https://hdl.handle.net/10400.17/3095 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..2c797ec5878971eb17ba2c41c781dadf |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |