The effect of nicotine administration on physical and psychological signs of withdrawal syndrome induced by single or frequent doses of morphine in rats
| العنوان: | The effect of nicotine administration on physical and psychological signs of withdrawal syndrome induced by single or frequent doses of morphine in rats |
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| المؤلفون: | Rafsanjani, A. T., Haghparast, A., Ali Shamsizadeh, Rohani, S. A. H., Roohbakhsh, A., Hakimizadeh, E., Amin, F., Allahtavakoli, M. |
| المصدر: | Basic and Clinical Neuroscience, Vol 3, Iss 3, Pp 49-57 (2012) Scopus-Elsevier |
| بيانات النشر: | Iran University of Medical Sciences, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Nicotine, Morphine, Withdrawal syndrome, Rat, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, lcsh:RC321-571 |
| الوصف: | Introduction. Morphine addiction and morphine withdrawal syndrome are the two main problems of today’s human society. The present study has investigated the effects of nicotine on the strength of physical and psychological dependency in single and repeated doses morphine administrated rats. Materials and methods. Male Wistar rats were subjected to morphine consumption with single or frequent dose protocols. In the single dose protocol, rats received only one dose of morphine and 24hrs later they also received one dose of nicotine 30 min prior to injection of naloxone. In the repeated dose protocol, rats received incremental doses of morphine for 7 days and 24hr after the last dose (the 8th day) were given naloxone. However, the nicotine regimen of this group was injected 15 min before the morphine injection, for 4 days, from the 4th to the 7th day. Five minutes after naloxone injection, each rat′s behavior was captured for 30 min, and then physical and psychological signs of withdrawal syndrome were recorded. Data were analyzed by ANOVA followed by Tukey tests and p |
| اللغة: | English |
| تدمد: | 2228-7442 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2e0476f502e8079ea2f002ab6b81023f http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-110&slc_lang=en&sid=1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..2e0476f502e8079ea2f002ab6b81023f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22287442 |
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