Environmental Mycobacterium avium subsp. paratuberculosis Hosted by Free-Living Amoebae
| العنوان: | Environmental Mycobacterium avium subsp. paratuberculosis Hosted by Free-Living Amoebae |
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| المؤلفون: | Samba-Louaka, Ascel, Robino, Etienne, Cochard, Thierry, BRANGER, Maxime, Delafont, Vincent, Aucher, Willy, Wambeke, Wilfrid, Bannantine, John, Biet, Franck, Héchard, Yann |
| المساهمون: | Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Microbiologie de l'Eau (MDE), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, 'Habisan program' (CPER-FEDER), Infectiologie Animale et Santé Publique - IASP (Nouzilly, France), Institut National de la Recherche Agronomique (INRA), INRA - U. Tours, UMR 1282 ISP Infectiologie et Santé Publique, Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT) |
| المصدر: | Frontiers in Cellular and Infection Microbiology Frontiers in Cellular and Infection Microbiology, Frontiers, 2018, 8, pp.1-7. ⟨10.3389/fcimb.2018.00028⟩ Frontiers in Cellular and Infection Microbiology, Vol 8 (2018) Frontiers in Cellular and Infection Microbiology, Frontiers Media, 2018, 8, ⟨10.3389/fcimb.2018.00028⟩ |
| بيانات النشر: | HAL CCSD, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Microbiology (medical), amoebae, [SDV]Life Sciences [q-bio], Immunology, water, lcsh:QR1-502, Rosculus, macromolecular substances, biochemical phenomena, metabolism, and nutrition, Microbiology, lcsh:Microbiology, infection, Mycobacterium, Infectious Diseases, paratuberculosis, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, parasitic diseases, ComputingMilieux_MISCELLANEOUS |
| الوصف: | International audience; Mycobacterium avium subsp. paratuberculosis is responsible for paratuberculosis in animals. This disease, leading to an inflammation of the gastrointestinal tract, has a high impact on animal health and an important economic burden. The environmental life cycle of M. avium subsp. paratuberculosis is poorly understood and several studies suggest that free-living amoebae (FLA) might be a potential environmental host. FLA are protozoa found in water and soil that are described as reservoirs of pathogenic and nonpathogenic bacteria in the environment. Indeed, bacteria able to survive within these amoebae would survive phagocytosis from immune cells. In this study, we assessed the in vitro interactions between several strains of M. avium subsp. paratuberculosis and Acanthamoeba castellanii. The results indicate that the bacteria were able to grow within the amoeba and that they can survive for several days within their host. To explore the presence of M. avium subsp. paratuberculosis in environmental amoebae, we sampled water from farms positive for paratuberculosis. A M. avium subsp. paratuberculosis strain was detected within an environmental amoeba identified as related to the poorly described Rosculus genus. The bacterial strain was genotyped, showing that it was similar to previous infectious strains isolated from cattle. In conclusion, we described that various M. avium subsp. paratuberculosis strains were able to grow within amoebae and that these bacteria could be found on farm within amoebae isolated from the cattle environment. It validates that infected amoebae might be a reservoir and vector for the transmission of M. avium subsp. paratuberculosis. |
| اللغة: | English |
| تدمد: | 2235-2988 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3766b9d6e7d425fe47dd9ce768f3509e https://hal.archives-ouvertes.fr/hal-01705081/document |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..3766b9d6e7d425fe47dd9ce768f3509e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22352988 |
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