LOW-DOSE EFFECTS OF IONIZING RADIATIONS IN IN VITRO AND IN VIVO BIOLOGICAL SYSTEMS: A MULTI-SCALE APPROACH STUDY
| العنوان: | LOW-DOSE EFFECTS OF IONIZING RADIATIONS IN IN VITRO AND IN VIVO BIOLOGICAL SYSTEMS: A MULTI-SCALE APPROACH STUDY |
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| المؤلفون: | Antoccia A, Argazzi E. b, Balata M, Bedogni R, Bisogni G, Bono M, Bottigli U, Brunetti A, Buttafava A, Castellani G, Centis F, Cesarini W, Cherubini R, Cossu A, Cugia G, Dattena M, De Nadal V, Dondi D, Esposito A, Faucitano A, Fiori P. L, Fusco E, Gerardi S, Laubenstein M, Lucarini A, Marengo M, Masala G. L, Nieri D, Nisi S, Picardi F, Pintus G, Posadino A, Randaccio P, Remondini D, Stramigioli S, Tanzarella C, Valentini M, Zamai L, Zini G, Zironi I., BERARDINELLI, FRANCESCO, SGURA, Antonella |
| المساهمون: | A. Antoccia, E. Argazzi, M. Balata, R. Bedogni, F. Berardinelli, G. Bisogni, M. Bono, U. Bottigli, A. Brunetti, A. Buttafava, G. Castellani, F. Centi, W. Cesarini, R. Cherubini, A. Cossu, G. Cugia, M. Dattena, V. De Nadal, D. Dondi, A. Esposito, A. Faucitano, P. L. Fiori, E. Fusco, S. Gerardi, M. Laubenstein, A. Lucarini, M. Marengo, G. L. Masala, D. Nieri, S. Nisi, F. Picardi, G. Pintu, A. Posadino, P. Randaccio, D. Remondini, A. Sgura, S. Stramigioli, C. Tanzarella, M. Valentini, L. Zamai, G. Zini, I. Zironi, Antoccia, A, Argazzi E., B, Balata, M, Bedogni, R, Berardinelli, Francesco, Bisogni, G, Bono, M, Bottigli, U, Brunetti, A, Buttafava, A, Castellani, G, Centis, F, Cesarini, W, Cherubini, R, Cossu, A, Cugia, G, Dattena, M, De Nadal, V, Dondi, D, Esposito, A, Faucitano, A, Fiori P., L, Fusco, E, Gerardi, S, Laubenstein, M, Lucarini, A, Marengo, M, Masala G., L, Nieri, D, Nisi, S, Picardi, F, Pintus, G, Posadino, A, Randaccio, P, Remondini, D, Sgura, Antonella, Stramigioli, S, Tanzarella, C, Valentini, M, Zamai, L, Zini, G, Zironi, I. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | ionizing radiation, apoptosis, cell survival, apoptosis, ionizing radiation, BIOLOGICAL EFFECTS, cell survival |
| الوصف: | ""Long-term biological effects of low-dose radiation are little known nowadays and its carcinogenic risk is estimated on the assumption that the risk remains linearly proportional to the radiation dose down to low-dose levels. However in the last 20 years this hypothesis has gradually begun to seem in contrast with a huge collection of experimental evidences, which has shown the presence of a plethora of non-linear phenomena (including hypersensitivity and induced radioresistance, adaptive response, and non-targeted phenomena like bystander effect and genomic instability) occurring after low-dose irradiation. These phenomena might imply a non-linear behaviour of cancer risk curves in the low-dose region and question the validity of the Linear No-Threshold (LNT) model currently used for cancer risk assessment through extrapolation from existing high-dose data. Moreover only few information is available regarding the effects induced on cryopreserved cells by multi-year background radiation exposure, which might induce a radiation-damage accumulation, due to the inhibition of cellular repair mechanisms. In this framework, the multi-year EXCALIBUR (EXposure effeCts At Low doses of Ionizing radiation in Biological CultURes) experiment, funded by INFN-CNS5, has undertaken a multiscale approach investigation on the biological effects induced in in vitro and in vivo biological systems, in culture and cryopreserved conditions, as a function of radiation quality (X\\\/γ-rays, protons, He-4 ions of various energies) and dose, with particular emphasis on the low-dose region and non-linear phenomena, in terms of different biological endpoints. PACS 87.53.-j-Effects of ionizing radiation on biological systems. PACS 87.53.Ay-Biophysical mechanisms of interaction. PACS 87.53.Bn-Dosimetry\\\/exposure assessment. PACS 87.18.Gh-Cell-cell communication; collective behavior of motile cells"" |
| وصف الملف: | STAMPA |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::499929546a83aa06331b29676d6fa0cd https://hdl.handle.net/11576/2601991 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..499929546a83aa06331b29676d6fa0cd |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |