Early and long-lasting alteration of effector CD45RA(-)Foxp3(high) regulatory T-cell homeostasis during HIV infection
| العنوان: | Early and long-lasting alteration of effector CD45RA(-)Foxp3(high) regulatory T-cell homeostasis during HIV infection |
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| المؤلفون: | Simonetta, Federico, Lecuroux, Camille, Girault, Isabelle, Goujard, Cécile, Sinet, Martine, Lambotte, Olivier, Venet, Alain, Bourgeois, Christine |
| المساهمون: | Régulation de la réponse immune, infection VIH-1 et autoimmunité, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de médecine interne et maladies infectieuses, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, This work was supported by the Agence Nationale de la recherche contre le SIDA et les hépatites virales (ANRS) and Fondation de France. F S was also supported by the Fondation pour la recherche médicale (FRM)., Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11) |
| المصدر: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2012, 205 (10), pp.1510-9. ⟨10.1093/infdis/jis235⟩ |
| بيانات النشر: | HAL CCSD, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | MESH: Aged, MESH: Humans, MESH: Middle Aged, FOXP3, MESH: T-Lymphocytes, Regulatory, virus diseases, HIV, hemic and immune systems, chemical and pharmacologic phenomena, MESH: Adult, MESH: Flow Cytometry, MESH: HIV Infections, MESH: Antigens, CD45, MESH: Case-Control Studies, MESH: Antiretroviral Therapy, Highly Active, AIDS, Treg, MESH: HIV-1, MESH: France, MESH: Homeostasis, MESH: Forkhead Transcription Factors, MESH: Cell Proliferation, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Antigens, CD8, MESH: Viral Load |
| الوصف: | International audience; Regulatory T-cell (Treg) quantification in human immunodeficiency virus (HIV) infection remains ill defined because of the lack of reliable specific markers to identify human Tregs and the diversity of clinical stages of HIV infection. Using a recently described Treg identification strategy based on CD45RA and Foxp3 expression, we performed an extensive quantification of total, naive (CD45RA(+)Foxp3(low)), and effector (CD45RA(-)Foxp3(high)) Tregs in different contexts of HIV infection: primary HIV infection, long-term viremic patients, aviremic patients treated with highly active antiretroviral therapy, and HIV controllers. We showed that although total Treg percentages were mildly affected by HIV infection, Treg absolute numbers were significantly reduced in all groups studied. We demonstrated that although naive Treg numbers were essentially preserved, effector Tregs were consistently affected during HIV infection. Finally, we demonstrated that effector but not total or naive Treg numbers were negatively correlated with the magnitude of HIV-specific CD8 T-cell responses. |
| اللغة: | English |
| تدمد: | 0022-1899 1537-6613 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4e189e180b3c6ffb79a02261786abd28 https://www.hal.inserm.fr/inserm-00865957 |
| رقم الأكسشن: | edsair.dedup.wf.001..4e189e180b3c6ffb79a02261786abd28 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00221899 15376613 |
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