Bifid T waves on the ECG and genetic variation in calcium channel voltage-dependent beta 2 subunit gene (CACNB2) in acute Kawasaki disease
| العنوان: | Bifid T waves on the ECG and genetic variation in calcium channel voltage-dependent beta 2 subunit gene (CACNB2) in acute Kawasaki disease |
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| المؤلفون: | Oyamada, J, Shimizu, C, Kim, J, Williams, MR, Png, E, Hibberd, ML, Tremoulet, AH, Perry, JC, Burns, JC |
| المصدر: | Congenital heart disease, vol 14, iss 2 Oyamada, J; Shimizu, C; Kim, J; Williams, MR; Png, E; Hibberd, ML; et al.(2018). Bifid T waves on the ECG and genetic variation in calcium channel voltage-dependent beta 2 subunit gene (CACNB2) in acute Kawasaki disease.. Congenital heart disease. doi: 10.1111/chd.12696. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6d40s7vj |
| بيانات النشر: | eScholarship, University of California, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Mucocutaneous Lymph Node Syndrome, Cardiorespiratory Medicine and Haematology, Cardiovascular, bifid T wave, Electrocardiography, Genetic, Genetics, Humans, 2.1 Biological and endogenous factors, Genetic Predisposition to Disease, Polymorphism, Aetiology, Child, Preschool, Kawasaki disease, ECG, Prevention, Human Genome, Infant, Genetic Variation, L-Type, Heart Disease, Cardiovascular System & Hematology, Echocardiography, Acute Disease, Female, calcium channel, Calcium Channels, Follow-Up Studies, Genome-Wide Association Study |
| الوصف: | BACKGROUND:We previously described the association of genetic variants in calcium channel genes and susceptibility to Kawasaki disease (KD), an acute, self-limited vasculitis, and the most common cause of acquired cardiac disease in children. Abnormal repolarization of cardiomyocytes and changes in T wave morphology have been reported in KD but have not been studied systematically. METHODS:We analyzed acute and convalescent ECG T wave morphology in two independent cohorts of KD subjects and studied the association between bifid T waves and genetic variants in previously reported genes with SNVs associated with cardiac repolarization. RESULTS:Bifid T waves in limb leads were identified in 24% and 27% of two independent cohorts of acute KD subjects. Calcium channel voltage-dependent beta 2 subunit gene (CACNB2) (rs1409207) showed association with bifid T waves in both cohorts (nominal P = .04 and P = .0003, respectively). This CACNB2 polymorphism also showed association with KD susceptibility in a previously published KD genome wide association study data (nominal P = .009). CONCLUSION:This genotype/phenotype association study uncovered a variant in CACNB2 that may be associated with both KD susceptibility and bifid T waves, a novel signature of altered myocardial repolarization. The present study combined with published reports suggests that genetic variants in calcium channels and intracellular calcium signaling play a prominent role in shaping susceptibility to KD. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::50945b106f42d2b5955b129e6be0af3e https://escholarship.org/uc/item/6d40s7vj |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..50945b106f42d2b5955b129e6be0af3e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |