Wnt signalling regulates adult hippocampal neurogenesis
| العنوان: | Wnt signalling regulates adult hippocampal neurogenesis |
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| المؤلفون: | Lie DC, Colamarino SA, Song HJ, Désiré L, Mira H, Consiglio A, Lein ES, Jessberger S, Lansford H, Dearie AR, Gage FH |
| المصدر: | Nature r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname |
| بيانات النشر: | NATURE PUBLISHING GROUP, 2005. |
| سنة النشر: | 2005 |
| الوصف: | The generation of new neurons from neural stem cells is restricted to two regions of the adult mammalian central nervous system: the subventricular zone of the lateral ventricle, and the subgranular zone of the hippocampal dentate gyrus. In both regions, signals provided by the microenvironment regulate the maintenance, proliferation and neuronal fate commitment of the local stem cell population. The identity of these signals is largely unknown. Here we show that adult hippocampal stem/progenitor cells (AHPs) express receptors and signalling components for Wnt proteins, which are key regulators of neural stem cell behaviour in embryonic development. We also show that the Wnt/beta-catenin pathway is active and that Wnt3 is expressed in the hippocampal neurogenic niche. Overexpression of Wnt3 is sufficient to increase neurogenesis from AHPs in vitro and in vivo. By contrast, blockade of Wnt signalling reduces neurogenesis from AHPs in vitro and abolishes neurogenesis almost completely in vivo. Our data show that Wnt signalling is a principal regulator of adult hippocampal neurogenesis and provide evidence that Wnt proteins have a role in adult hippocampal function. |
| تدمد: | 0028-0836 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::625248c1d88b44968369ad3d75699414 http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12120 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..625248c1d88b44968369ad3d75699414 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00280836 |
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