The changing epidemiology of Ebstein's anomaly and its relationship with maternal mental health conditions: a European registry-based study
| العنوان: | The changing epidemiology of Ebstein's anomaly and its relationship with maternal mental health conditions: a European registry-based study |
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| المؤلفون: | Boyle B, Garne E, Loane M, Addor MC, Arriola L, Cavero-Carbonell C, Gatt M, Lelong N, Lynch C, Nelen V, Neville AJ, O'Mahony M, Pierini A, Rissmann A, Tucker D, Zymak-Zakutnia N, Dolk H |
| المصدر: | CARDIOLOGY IN THE YOUNG r-FISABIO. Repositorio Institucional de Producción Científica instname r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| بيانات النشر: | CAMBRIDGE UNIV PRESS, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Ebstein's anomaly, antidepressants, prevalence, psycholeptics, mental illness |
| الوصف: | Objectives: The aim of this study was to describe the epidemiology of Ebstein's anomaly in Europe and its association with maternal health and medication exposure during pregnancy. Design: We carried out a descriptive epidemiological analysis of population-based data. Setting: We included data from 15 European Surveillance of Congenital Anomalies Congenital Anomaly Registries in 12 European countries, with a population of 5.6 million births during 1982-2011. Participants: Cases included live births, fetal deaths from 20 weeks gestation, and terminations of pregnancy for fetal anomaly. Main outcome measures: We estimated total prevalence per 10,000 births. Odds ratios for exposure to maternal illnesses/medications in the first trimester of pregnancy were calculated by comparing Ebstein's anomaly cases with cardiac and non-cardiac malformed controls, excluding cases with genetic syndromes and adjusting for time period and country. Results: In total, 264 Ebstein's anomaly cases were recorded; 81% were live births, 2% of which were diagnosed after the 1st year of life; 54% of cases with Ebstein's anomaly or a co-existing congenital anomaly were prenatally diagnosed. Total prevalence rose over time from 0.29 (95% confidence interval (CI) 0.20-0.41) to 0.48 (95% CI 0.40-0.57) (p < 0.01). In all, nine cases were exposed to maternal mental health conditions/medications (adjusted odds ratio (adjOR) 2.64, 95% CI 1.33-5.21) compared with cardiac controls. Cases were more likely to be exposed to maternal beta-thalassemia (adjOR 10.5, 95% CI 3.13-35.3, n = 3) and haemorrhage in early pregnancy (adjOR 1.77, 95% CI 0.93-3.38, n = 11) compared with cardiac controls. Conclusions: The increasing prevalence of Ebstein's anomaly may be related to better and earlier diagnosis. Our data suggest that Ebstein's anomaly is associated with maternal mental health problems generally rather than lithium or benzodiazepines specifically; therefore, changing or stopping medications may not be preventative. We found new associations requiring confirmation. |
| تدمد: | 1047-9511 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::820f8f4bb3b859cd77cd5352d107262d https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1561 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..820f8f4bb3b859cd77cd5352d107262d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10479511 |
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