Ion channel based development of biosensors for discovering improved treatments for amyotrophic lateral sclerosis
| العنوان: | Ion channel based development of biosensors for discovering improved treatments for amyotrophic lateral sclerosis |
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| المؤلفون: | Núñez, Eider, Campos, Igone, Araujo, Ariane, Muguruza-Montero, Arantza, Malo, Covadonga, Urrutia, Janire, Villarroel, Álvaro, Alicante Martínez, Sara |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Riluzole, Calmodulin, SK4 Channel, Amyotrophic lateral sclerosis, Biosensor |
| الوصف: | Resumen del trabajo presentado al 8th International Iberian Biophysics Congress celebrado en Bilbao los días 20 y 21 de junio de 2022. Calmodulin recognizes more than 300 different targets with very little sequence similarity. Those targets control key events on human physiology with great therapeutically potential [1]. We are working on creating a library of biosensors with the aim of capturing the key molecular rearrangements that take place in different full-length ligands, an connecting those events to easily detectable fluorescent signals amenable of high throughput screening. As a proof of concept, we will present the development of a biosensor that recapitulates the most essential effects of Riluzole, the only drug available for treatment of amyotrophic lateral sclerosis. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8e56b1beb78a525e833b7292c87aad5f http://hdl.handle.net/10261/309960 |
| رقم الأكسشن: | edsair.dedup.wf.001..8e56b1beb78a525e833b7292c87aad5f |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |