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Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy

التفاصيل البيبلوغرافية
العنوان: Sirtuins: To Be or Not To Be in Diabetic Cardiomyopathy
المؤلفون: Palomer FX, Aguilar-Recarte D, García R, Nistal JF, Vazquez M
المصدر: TRENDS IN MOLECULAR MEDICINE
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
بيانات النشر: Elsevier BV, 2021.
سنة النشر: 2021
مصطلحات موضوعية: inflammation, myocardial fibrosis, sirtuin, diabetic cardiomyopathy, metabolic dysregulation, oxidative stress
الوصف: Diabetic cardiomyopathy is the leading cause of death among people with diabetes. Despite its severity and poor prognosis, there are currently no approved specific drugs to prevent or even treat diabetic cardiomyopathy. There is a need to understand the pathogenic mechanisms underlying the development of diabetic cardiomyopathy to design new therapeutic strategies. These mechanisms are complex and intricate and include metabolic dysregulation, inflammation, oxidative stress, fibrosis, and apoptosis. Sirtuins, a group of deacetylase enzymes, play an important role in all these processes and are, therefore, potential molecular targets for treating this disease. In this review, we discuss the role of sirtuins in the heart, focusing on their contribution to the pathogenesis of diabetic cardiomyopathy and how their modulation could be therapeutically useful.
تدمد: 1471-4914
URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::92c7193db4ebb829e1187953c3a38480
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19388
حقوق: OPEN
رقم الأكسشن: edsair.dedup.wf.001..92c7193db4ebb829e1187953c3a38480
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14714914