The role of parvovirus B19 and the immune response in the pathogenesis of acute leukemia
| العنوان: | The role of parvovirus B19 and the immune response in the pathogenesis of acute leukemia |
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| المؤلفون: | Kerr, JR, Mattey, DL |
| المصدر: | Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| بيانات النشر: | John Wiley and Sons Ltd, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Parvoviridae infections, Physiology, viruses, Pathogenesis, Review, Hla antigen class 2, Acute lymphoblastic leukemia, Hla antigen class 1, Cytokine production, Time factor, Human parvovirus b19, Interleukin 10, hemic and lymphatic diseases, Immunoglobulin g, Disease course, Child, Middle aged, Allele, Leukemia, Human parvovirus b19 infection, Virus cell transformation, virus diseases, Cancer diagnosis, Antineoplastic agent, Female, Cancer chemotherapy, Human, Virus diseases, viral, Adult, Adolescent, Tumor gene, Virus infection, Aplastic crisis, Immunology, Methylation, preschool, Disease association, Virology, Antineoplastic combined chemotherapy protocols, Case report, Humans, Immune response, Parvovirus infection, Aged, Acute leukemia, Erythroblast, Time factors, Infant, Parvovirus b19, R1, Young adult, Preschool child, Cell transformation, Mutation, Complication, Erythrocyte lifespan |
| الوصف: | In this article, we review the evidence suggesting a possible role for B19 virus in the pathogenesis of a subset of cases of acute leukemia. Human parvovirus B19 infection may complicate the clinical course of patients with acute leukemia and may also precede the development of acute leukemia by up to 180 days. Parvovirus B19 targets erythroblasts in the bone marrow and may cause aplastic crisis in patients with shortened-red cell survival. Aplastic crisis represents a prodrome of acute lymphoblastic leukemia in 2% patients. There is a significant overlap between those HLA classes I and II alleles that are associated with a vigorous immune response and development of symptoms during B19 infection and those HLA alleles that predispose to development of acute leukemia. Acute symptomatic B19 infection is associated with low circulating IL-10 consistent with a vigorous immune response; deficient IL-10 production at birth was recently found to be associated with subsequent development of acute leukemia. Anti-B19 IgG has been associated with a particular profile of methylation of human cancer genes in patients with acute leukemia, suggesting an additional hit and run mechanism. The proposed role for parvovirus B19 in the pathogenesis of acute leukemia fits well with the delayed infection hypothesis and with the two-step mutation model, which describes carriage of the first mutation prior to birth, followed by suppression of hematopoiesis, which allows rapid proliferation of cells harboring the first mutation, acquisition of a second activating mutation, and expansion of cells carrying both mutations, resulting in acute leukemia. Copyright © 2015 John Wiley & Sons, Ltd. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1052-9276 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::944b609181e57913afd49247d1f69712 https://repository.urosario.edu.co/handle/10336/22951 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..944b609181e57913afd49247d1f69712 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10529276 |
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