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Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved]

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العنوان: Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved]
المؤلفون: Fawcett, KA, Obeidat, M, Melbourne, C, Shrine, N, Guyatt, AL, John, C, Luan, J, Richmond, A, Moksnes, MR, Granell, R, Weiss, S, Imboden, M, May-Wilson, S, Hysi, P, Boutin, TS, Portas, L, Flexeder, C, Harris, SE, Wang, CA, Lyytikäinen, LP, Palviainen, T, Foong, RE, Keidel, D, Minelli, C, Langenberg, C, Bossé, Y, Van den Berge, M, Sin, DD, Hao, K, Campbell, A, Porteous, D, Padmanabhan, S, Smith, BH, Evans, DM, Ring, S, Langhammer, A, Hveem, K, Willer, C, Ewert, R, Stubbe, B, Pirastu, N, Klaric, L, Joshi, PK, Patasova, K, Massimo, M, Polasek, O, Starr, JM, Karrasch, S, Strauch, K, Meitinger, T, Rudan, I, Rantanen, T., Pietiläinen, K, Kähönen, M, Raitakari, OT, Hall, GL, Sly, PD, Pennell, CE, Kaprio, J, Lehtimäki, T, Vitart, V, Deary, IJ, Jarvis, D, Wilson, JF, Spector, T, Probst-Hensch, N, Wareham, NJ, Völzke, H, Henderson, J, Strachan, DP, Brumpton, BM, Hayward, C, Hall, IP, Tobin, MD, Wain, LV
المصدر: Wellcome Open Research, Vol 5 (2020)
بيانات النشر: Wellcome, 2020.
سنة النشر: 2020
مصطلحات موضوعية: genome-wide interaction study, HHIP, lcsh:R, lcsh:Medicine, lung function, genotyyppi, sukupuoli, hengityselimet, toimintakyky, expression, sex, lcsh:Q, geeniekspressio, geneettiset tekijät, lcsh:Science, keuhkot
الوصف: Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P
وصف الملف: application/pdf; fulltext
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::96845324410f966bd4bc0574c646612b
https://wellcomeopenresearch.org/articles/5-111/v1
حقوق: OPEN
رقم الأكسشن: edsair.dedup.wf.001..96845324410f966bd4bc0574c646612b
قاعدة البيانات: OpenAIRE
الوصف
الوصف غير متاح.