Influence of liposomal platinum cytostatics on cancer cells by voltammetric methods
| العنوان: | Influence of liposomal platinum cytostatics on cancer cells by voltammetric methods |
|---|---|
| المؤلفون: | Sedlackova, E., Lanikova, P., Hynek, D., Krejcova, L., Buchtelova, H., Lukas Richtera, Adam, V. |
| المصدر: | NANOCON 2017. 2018, p. 548-553. Scopus-Elsevier |
| بيانات النشر: | TANGER, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | liposomes, cancer cell lines, electrochemistry, Cisplatin, differential pulse voltammetry |
| الوصف: | Aim of this work deals with closing of cisplatin into liposomes, the study of their stability and interaction with cancer cell lines. Commercial cisplatin cytostatic was encapsulated into three types of liposomes (L8, L10 and L15) of a different chemical composition. Each of liposomes had different ability to close cytostatic. L8 differs from L10 by containing cholesterol. In despite of L10 and L8, L15 liposome contains a synthetic 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (C41H78NO8P) – DOPE, which is generally found in cell membranes. The size of the liposomes was characterized by Dynamic Light Scattering (DLS). The amount of Pt-drug in liposomes was verified by electrochemical determination. Their stability was observed by differential pulse voltammetry (DPV). These studies also demonstrated, that the cisplatin is stable in physiological solution for at least 24 hours, which making it a suitable medium storage for this drug. Finally, the encapsulated cisplatin was applied to cancer cell lines and their viability was observed by MTT assay. |
| وصف الملف: | text; application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::9801c354711915f9d89cf42be8562be1 https://hdl.handle.net/11012/178375 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.dedup.wf.001..9801c354711915f9d89cf42be8562be1 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |