Chiappini, C, Campagnolo, P, Almeida, C S, Abbassi-Ghadi, N, Chow, L W, Hanna, G B & Stevens, M M 2015, ' Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles ', Advanced materials (Deerfield Beach, Fla.), vol. 27, no. 35, pp. 5147-5152 . https://doi.org/10.1002/adma.201501304
Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma.
