أعرض في EDS

Cryptococcal meningoencephalitis: time for action

التفاصيل البيبلوغرافية
العنوان: Cryptococcal meningoencephalitis: time for action
المؤلفون: Stott, KE, Loyse, A, Jarvis, JN, Alufandika, M, Harrison, TS, Mwandumba, HC, Day, JN, Lalloo, DG, Bicanic, T, Perfect, JR, Hope, W
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
مصطلحات موضوعية: qw180, wl_300
الوصف: Cryptococcal meningoencephalitis was first described over a century ago. This fungal infection is preventable and treatable yet continues to be associated with excessive morbidity and mortality. The largest burden of disease resides in people living with HIV in low-income and middle-income countries. In this group, mortality with the best antifungal induction regimen (7 days of amphotericin B deoxycholate [1·0 mg/kg per day] and flucytosine [100·0 mg/kg per day]) in a clinical trial setting was 24% at 10 weeks. The world is now at an inflection point in terms of recognition, research, and action to address the burden of morbidity and mortality from cryptococcal meningoencephalitis. However, the scope of interventional programmes needs to increase, with particular attention to implementation science that is specific to individual countries. This Review summarises causes of excessive mortality, interventions with proven survival benefit, and gaps in knowledge and practice that contribute to the ongoing high death toll from cryptococcal meningoencephalitis. TRANSLATIONS: For the Vietnamese and Chichewa translations of the abstract see Supplementary Materials section.
وصف الملف: application/pdf
اللغة: English
تدمد: 1473-3099
1474-4457
URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b14611251d3eb126443ebe48728a4309
حقوق: OPEN
رقم الأكسشن: edsair.dedup.wf.001..b14611251d3eb126443ebe48728a4309
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14733099
14744457