ACTIVIDAD ANTIPLASMODIAL DE ALCALOIDES APORFÍNICOS DE Rollinia pittieri Y Pseudomalmea boyacana (ANNONACEAE)
| العنوان: | ACTIVIDAD ANTIPLASMODIAL DE ALCALOIDES APORFÍNICOS DE Rollinia pittieri Y Pseudomalmea boyacana (ANNONACEAE) |
|---|---|
| المؤلفون: | Edison J. OSORIO D., Guillermo L. MONTOYA P., Katalina MUÑOZ D., Gabriel J. ARANGO A. |
| المصدر: | Vitae, Volume: 13, Issue: 1, Pages: 49-54, Published: MAR 2006 Vitae, Vol 13, Iss 1 (2009) |
| بيانات النشر: | Facultad de Química Farmacéutica, Universidad de Antioquia, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | plantas colombianas, aporphine alkaloids, actividad antiplasmodial, Annonaceae, colombian plants, TP368-456, HD9665-9675, antiplasmodial activity, colombian plants and aporphine alkaloids, Food processing and manufacture, Pharmaceutical industry, alcaloides aporfínicos |
| الوصف: | In the course of from ethnobotanical or chemotaxonomical studies on biologically active substances with antiparasitic effects from Anonaceae colombian plants, substantial antiplasmodial activity was observed from the ethyl acetate extract of the stem of Rollinia pittieri and Pseudomalmea boyacana (Annonaceae), the alkaloids isolated from these were studied. Of the alkaloids, liriodenine exhibited the highest activity against chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum (CI50 = 8.0-10.0 μg/ml). In addition, inhibition of β-hematin formation (If????-h) by isolated compounds was evaluated (Ifs-h). O-methylmoschatoline and melosmine showed inhibition percentage >96% at 2 mg/ml. Some degree of cytotoxic to U-937 cells activity was observed by oxoporphine alkaloids. |
| وصف الملف: | text/html |
| اللغة: | Spanish; Castilian |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cb0623ce38a003cc4ab544dd1185b75e http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-40042006000100007&lng=en&tlng=en |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..cb0623ce38a003cc4ab544dd1185b75e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |