The importance of including toxicity assays when screening plant extracts for antimalarial activity
| العنوان: | The importance of including toxicity assays when screening plant extracts for antimalarial activity |
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| المؤلفون: | Dyk, S., Griffiths, S., Robyn Van Zyl, Malan, S. F. |
| المساهمون: | 10065911 - Van Dyk, Sandra, 10199667 - Malan, Sarel Francois |
| المصدر: | African Journal of Biotechnology; Vol 8, No 20 (2009) Scopus-Elsevier |
| بيانات النشر: | Academic Journals (Kenya), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Combretum erythrophyllum, Maytenus heterophylla, Antiplasmodial, Combretum erythrophyllum, Crinum bulbispermum, Maytenus heterophylla, Pavetta gardeniifolia, lycorine, Pavetta gardeniifolia, Crinum bulbispermum, Lycorine, Antiplasmodial |
| الوصف: | Identifying plant extracts as sources of antimalarial compounds needs to be addressed as numerous studies screen extracts without the means of eliminating extracts that are merely cytotoxic. Fifty-nine organic solvent extracts from South African plants were screened for antiplasmodial activity using the [3H]-hypoxanthine incorporation assay against the chloroquine-resistant Plasmodium falciparum. Variable antiplasmodial activity and toxicity was observed. Extracts form Combretum erythrophyllum and Crinum bulbispermum, had IC50 values ≤ 1 μg/ml with the ethyl acetate extracts of C. bulbispermum roots and bulbs having values comparable to chloroquine (0.04 µg/ml). Nine extracts had toxicity indexes ≥ 100. Lycorine, isolated from C. bulbispermum was as active as chloroquine (IC50 of 0.03 µg/ml) and had a favourable security index. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1684-5315 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ee018fb54d6489019a9028e64da7265c https://www.ajol.info/index.php/ajb/article/view/66014 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..ee018fb54d6489019a9028e64da7265c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16845315 |
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