Increase of CXCR4 Expression on Expanded Non-enriched Cord Blood CD34+ Cells Using MSCs
| العنوان: | Increase of CXCR4 Expression on Expanded Non-enriched Cord Blood CD34+ Cells Using MSCs |
|---|---|
| المؤلفون: | Soleimani, M., Mozdarani, H., Pourfathollah, A. A., Yousef Mortazavi, Alimoghaddam, K., Hajifathali, A., Zonobi, Z. |
| المصدر: | Cell Journal, Vol 7, Iss 2, Pp 74-79 (2005) Scopus-Elsevier |
| بيانات النشر: | Royan Institute (ACECR), Tehran, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | cord blood stem cells, CXCR4, Expansion, lcsh:R, lcsh:Medicine, lcsh:Q, CD44, lcsh:Science, hMSCs |
| الوصف: | Introduction: A number of potential cell adhesion molecules, which mediate essential cell-to-cell or cell-to-matrix interactions, are expressed on the surface of CD34+ hematopoietic progenitor cells (HPCs), including integrins, CD44, and CXCR4. These molecules are essential for homing process. In this study, we compared the changes of expression of CD44 and CXCR4 on the CD34+ hematopoietic progenitor cells expanded on MSCs in the presence of cytokines. Material and Methods: Cord blood CD34+ cells were expanded using human bone marrow mesenchymal stem cells and cytokines (TPO, SCF, FLt-3, IL-6, and IL-3), and then expression of CD44 and CXCR4 on CD34+ cells were evaluated by flow cytometric analysis. Results: After 2 weeks of serum free culture of CD34+ cells in the presence of cytokines, the expression of CXCR4 on CD34+ cells was decreased 3.4 fold (p |
| اللغة: | English |
| تدمد: | 2228-5814 2228-5806 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f9ef68a9ddadfdf7c7314a05af675b62 http://celljournal.org/library/upload/article/74-79.ps.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.dedup.wf.001..f9ef68a9ddadfdf7c7314a05af675b62 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22285814 22285806 |
|---|