Objective To investigate the relationship between methylenetetrahydrofolate reductase(MTHFR) G1793A genetic polymorphism and ulcerative colitis(UC) in the Zhejiang Han population.Methods A total of 209 patients with UC and 434 healthy collators were examined in the current study.The polymerase chain reaction-restriction fragment length polymorphism method was adopted to detect the distribution of MTHFR G1793A allelic gene and genotypic frequency.Results The frequencies of the MTHFR G1793A allelic gene and variant genotype GA+AA among UC patients were significantly higher than that in the healthy control group(23.21% vs 15.32%,P=0.001,OR=1.670,95% CI: 1.246-2.238;37.80% vs 25.81%,P=0.002,OR=1.747,95% CI: 1.228 to 2.486).Furthermore,stratified analysis of the clinical characteristics of UC patients showed that the frequencies of the G1793A allelic gene and the variant genotype GA+AA increased significantly among patients with extensive colitis compared with the patients with distal colitis(25.58% vs 12.36%,P=0.0006,OR=0.351,95% CI: 0.220-0.559;56.09% vs 25.98%,P=0.0001,OR=0.275,95% CI: 0.152-0.495).Conclusions The frequencies of the allelic gene variant of MTHFR G1793A and genotype were significantly increased among patients with UC in the Zhejiang Han population,which suggests that the genetic mutation may increase the risk of UC and have an effect on the region affected by UC.
