A randomized, controlled, double-blinded and double-dummy trial of the effect of Tongjiang Granule (通降颗粒) on the nonerosive reflux disease of and Gan (肝)-Wei (胃) incoordination syndrome
| العنوان: | A randomized, controlled, double-blinded and double-dummy trial of the effect of Tongjiang Granule (通降颗粒) on the nonerosive reflux disease of and Gan (肝)-Wei (胃) incoordination syndrome |
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| المؤلفون: | Bao-Shuang Li, Feng-Yun Wang, Zhen-Hua Li, Ping Wang, Yin-Qiang Zhang, Li-Ying Zhang, Li-Qun Bian, Ying-pan Zhao, Xu-Dong Tang |
| المصدر: | Chinese Journal of Integrative Medicine. 17:339-345 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | medicine.medical_specialty, Traditional medicine, business.industry, Nerd, Double blinded, Reflux, Case-control study, General Medicine, law.invention, Complementary and alternative medicine, Randomized controlled trial, Quality of life, law, Internal medicine, Medicine, Pharmacology (medical), General health, business, Adverse effect |
| الوصف: | To assess the effectiveness of Tongjiang Granule (TJG, 通降颗粒) on the patients with nonerosive reflux disease (NERD) of Gan (肝)-Wei (胃) incoordination syndrome, its impact on their quality of life, and its safety. A randomized, controlled, double-blinded, and double-dummy method was adopted in the trial. There were 120 NERD patients enrolled in the study and randomly divided into the experiment and control groups, each with 60 patients; drugs were distributed according to the drug number by patients’ inclusion sequences. In the experiment group, patients were given TJG 10 g and mosapride citrate dummy 5 mg three times a day, and in the control group, patients were given mosapride citrate 5 mg and TJG dummy 10 g three times a day. The treatment courses of both groups were 4 weeks. Among 120 included patients, 112 were screened for full analysis set (FAS), and 105 were screened per-protocol set (PPS). The results were as follows: (1) the improvement of total scores of symptom in the experiment group (0–4 week) were 15.93±7.88 scores by FAS and 16.22 ±7.75 scores by PPS, and they were 10.43±10.16 scores and 10.79±10.27 scores in the control group, respectively. The 95% CI of net scores improvement between the two groups were 2.10–8.90 scores and 1.92–8.94 scores in FAS and PPS; it was significantly better in the experiment group than that in the control group (P |
| تدمد: | 1993-0402 1672-0415 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::00302aab21ab57f4091264fa74286fc0 https://doi.org/10.1007/s11655-011-0724-0 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........00302aab21ab57f4091264fa74286fc0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19930402 16720415 |
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