Advancing the use of molecularly imprinted polymers in bioanalysis: the selective extraction of cotinine in human urine
| العنوان: | Advancing the use of molecularly imprinted polymers in bioanalysis: the selective extraction of cotinine in human urine |
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| المؤلفون: | Haley A Mulder, Thomas I Cecil, Cory Fines, Adam C Pearcy, Matthew S Halquist |
| المصدر: | Bioanalysis. |
| بيانات النشر: | Future Science Ltd, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Medical Laboratory Technology, Clinical Biochemistry, General Medicine, General Pharmacology, Toxicology and Pharmaceutics, Analytical Chemistry |
| الوصف: | Aim: To characterize a molecularly imprinted polymer via precipitation polymerization for the extraction of cotinine in urine. Methods: The polymer was created via precipitation polymerization. Physical characteristics of the polymer were assessed via scanning electron microscopy, Fourier transform infrared spectroscopy and thermogravimetric analysis. The polymer adsorption capacity was assessed and an SPE method from urine by LC–MS/MS was developed. Results: The polymer had small, spherical morphology and little thermal decomposition. The extraction method yielded cotinine recoveries of 77–103% in urine. The molecularly imprinted polymer adsorption capacity for cotinine was 448.2 ± 2.1 μg/mg. Common interferants did not affect cotinine's extraction. Conclusion: The resulting polymer was determined to be specific for cotinine and can be used for the detection of cotinine in urine for clinical samples. |
| تدمد: | 1757-6199 1757-6180 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::02243489cf4ead24b481bf1d095a3886 https://doi.org/10.4155/bio-2023-0019 |
| رقم الأكسشن: | edsair.doi...........02243489cf4ead24b481bf1d095a3886 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17576199 17576180 |
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