BackgroundThe clinical value of polygenic risk scores has been questioned. We sought to clarify performance in population screening, individual risk prediction and population risk stratification by analysing 926 polygenic risk scores for 310 diseases from the Polygenic Score (PGS) Catalog.MethodsPolygenic risk scores in the PGS Catalog are reported using hazard ratios or odds ratios per standard deviation, or the area under the receiver operating characteristic curve sometimes expressed as theC-index. We used this information to produce estimates of performance in: (a)population screening— by calculating the detection rate (DR5) for a 5% false positive rate (FPR) and the population odds of becoming affected given a positive result (OAPR); (b)individual risk prediction— by calculating the individual odds of becoming affected for a person with a particular polygenic score; and (c)population risk stratification— by calculating the odds of becoming affected for groups of individuals in different portions of a polygenic risk score distribution. We use coronary artery disease and breast cancer as illustrative examples.FindingsPopulation screening performance: The medianDR5for all polygenic risk scores and all diseases studied was 11% [interquartile range 8 − 18%]. The medianDR5was 12% [9 − 19] for polygenic risk scores for CAD and 10% [9 − 12] for breast cancer, with populationOAPRsof 1:8 and 1: 21 respectively, with background 10-year odds of 1:19 and 1:41 respectively, which are typical for these diseases at age 50.Individual risk prediction: The corresponding 10-year odds of becoming affected for individuals aged 50 with a polygenic risk score at the 2.5th, 25th, 75thand 97.5thcentile were 1:54, 1:29, 1:15, and 1:8 for CAD and 1:91, 1:56, 1:34, and 1:21 for breast cancer.Population risk stratification: At age 50, stratifying into quintile groups of CAD risk yielded 10-year odds of 1: 41 and 1: 11 for the lowest and highest quintile groups respectively. The 10-year odds was 1: 7 for the upper 2.5% of the polygenic risk score distribution for CAD, a group that contributed 7% of cases. The corresponding estimates for breast cancer were 1: 72 and 1: 26 for lowest and highest quintiles; and 1:19 for the upper 2.5% of the distribution, which contributed 6% of cases.InterpretationPolygenic risk scores perform poorly in population screening, individual risk prediction, and population risk stratification.FundingBritish Heart Foundation; UK Research and Innovation; National Institute of Health and Care Research.
