645 Topical Application of a Novel Powdered Scaffold for Rapid Treatment of Skin Injuries
| العنوان: | 645 Topical Application of a Novel Powdered Scaffold for Rapid Treatment of Skin Injuries |
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| المؤلفون: | Ruhangiz T. Kilani, Breshell Russ, Myriam Maude Verly, Reza B. Jalili, Aziz Ghahary |
| المصدر: | Journal of Burn Care & Research. 41:S168-S169 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Infection risk, Scaffold, Pathology, medicine.medical_specialty, integumentary system, business.industry, Rehabilitation, Powder dose form, Skin transplantation, Epidermis (zoology), Emergency Medicine, Medicine, Surgery, Wound closure, business, Wound healing |
| الوصف: | Introduction In large skin injuries, lack of matrix deposition impedes timely healing process. The longer a wound remains open, the greater is the risk of infection, non-healing, and other complications. It is therefore crucial to find effective means to promote rapid closure of skin defects. Our group has previously developed a liquid in situ-forming nutritional scaffold, known as MeshFill (MF). MF has been previously proven to be very effective in accelerating the wound repair process, notably that of complex wounds. However, MF is limited in its application to deep and tunnelling wounds, and requires reconstitution with a solvent as well as maintenance at cold temperature until application. To address these limitations, our group has developed a powdered form of MF for rapid topical application on superficial skin injuries such as dehisced surgical wounds and burn injuries. Methods Our goal was to investigate whether a powdered form of MF could be directly applied onto the wounds to accelerate healing. Ideally, powdered MF would absorb the moisture within the wound environment and reconstitute into the gel form in situ. We examined the efficacy of powder MF (PMF) compared to reconstituted gel MF (GMF) and to a standard dressing protocol. To do so, splinted full thickness wounds were generated on the back of mice and treated with either PMF or GMF or were bandaged with no treatment (NT). The healing process was monitored until wounds were fully closed. Clinical wound measurements and histological assessments were performed to compare different treatment regimens. Results Application of both PMF and GMF accelerated wound epithelialization at days 7 and 14, compared to NT, and had faster wound closure times. On average, the PMF treatments healed 17% faster than the NT control, and the GMF treatments healed 21% faster than the NT control. No significant difference between PMF and GMF was found for any outcomes. Additionally, our results suggest that epidermis formation was more effective in P and MF conditions compared to NT. Conclusions These findings suggest that topical application of a powdered form of MeshFill is as effective as standard reconstituted MeshFill gel in accelerating the healing process of skin injuries. Applicability of Research to Practice Topical application of a powdered scaffold may be a very convenient and practical method for rapid treatment of large superficial wounds such as dehisced surgical wounds, burn injuries, and filling gaps in meshed skin grafts. |
| تدمد: | 1559-0488 1559-047X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::02c320c06b23968ec31df7a409f970c1 https://doi.org/10.1093/jbcr/iraa024.265 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........02c320c06b23968ec31df7a409f970c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590488 1559047X |
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