Three times of intratumor injection of the sustained released by ROS with penicillin-combined chemotherapy drugs for the long of survival period of the tumor-bearing mouse
| العنوان: | Three times of intratumor injection of the sustained released by ROS with penicillin-combined chemotherapy drugs for the long of survival period of the tumor-bearing mouse |
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| المؤلفون: | Jian Zhang, Yan Han, Guoqin Zheng, Ming Zhao, Dong Chen, Bian Li, Baofa Yu, Qiang Fu |
| المصدر: | Journal of Clinical Oncology. 38:e22098-e22098 |
| بيانات النشر: | American Society of Clinical Oncology (ASCO), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Penicillin, Cancer Research, Survival period, Oncology, business.industry, medicine, Combination chemotherapy, Pharmacology, business, Hapten, medicine.drug |
| الوصف: | e22098 Background: To study the effect of sustained release by ROS with hapten for three intratumoral injections of chemical drugs on the survival of tumor-bearing mice. Methods: Mice bearing solid tumors of H22 liver cancer were randomly divided into groups with the longest tumor diameter of about 4-7 mm. They were administered intratumorally the next day, with a second interval of 7 days and an interval of 14 days (the 15th day of the experiment). During the period of administration and observation, the death of mice was observed daily, and the time of death was recorded to calculate the life extension rate. Results: The weight of mice in group Ⅲ and group Ⅳ was lower than that in control group, suggesting that chemotherapeutic drugs caused damage of mice and did not significantly increase body weight. Tumor size: Tumor volume experimental groups were different from the Control group, showing a significant anti-tumor effect; but there was no difference compared with Dox Control. Survival The survival rate of each group of mice is closely related to the tumor progression and drug treatment. The survival rate of each group after 45 days of treatment is significantly higher than that of the Control group. The average survival time of group Ⅳ, group Ⅰ and group Ⅱ was longer than that of control group with significant difference. Conclusions: After intratumoral injection 3 times, the survival time of mice is been prolonged. |
| تدمد: | 1527-7755 0732-183X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::02f26e51cf92997b4b3e3e6a47e9a9ba https://doi.org/10.1200/jco.2020.38.15_suppl.e22098 |
| رقم الأكسشن: | edsair.doi...........02f26e51cf92997b4b3e3e6a47e9a9ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15277755 0732183X |
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