Pancytopenia, panhypopituitarism and liver cirrhosis: analysis of a difficult clinical case
| العنوان: | Pancytopenia, panhypopituitarism and liver cirrhosis: analysis of a difficult clinical case |
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| المؤلفون: | Pavel Polák, Jana Michalcová, Jiřina Zavřelová, Jan Kamelander, Václav Odstrčilík, Miroslav Penka, Tomáš Rohan, Libor Červinek, Zuzana Pazdičová |
| المصدر: | Vnitřní lékařství. 65:715-720 |
| بيانات النشر: | Solen s.r.o., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Cirrhosis, biology, business.industry, 030209 endocrinology & metabolism, medicine.disease, Chronic liver disease, Pancytopenia, Gastroenterology, Protein S, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Internal Medicine, medicine, Paroxysmal nocturnal hemoglobinuria, biology.protein, Portal hypertension, Cardiology and Cardiovascular Medicine, Viral hepatitis, business, Hemochromatosis |
| الوصف: | Panhypopituitarism following craniopharyngioma resection has systemic impact with potential influence on physio-logical hematopoiesis. There is a growing body of evidence of liver fibrosis/cirrhosis risk development due to altered metabolism and lipid accumulation. The authors present a case report of a woman with a history of craniopharyngioma resection followed by aggravating pancytopenia with suspected indolent lymphoproliferative disorder and possible acquired bone marrow aplasia syndrome due to paroxysmal nocturnal hemoglobinuria. A complex hemostasis disorder with deficiency of multiple coagulation factors (FXII, FXI, FX, FIX, FVII, FX, FV, FXIII, antitrombin, protein C, protein S) was accidentally detected. Despite normal sonographic liver imaging, all possible causes of chronic liver disease were systematically excluded (viral hepatitis, hemochromatosis, Wilson´s disease, α-1-antitrypsin deficiency); anti-LKM-1 and anti-ENA antibodies were detected. Finally, the magnetic resonance imaging confirmed image of liver cirrhosis - with signs of portal hypertension. |
| تدمد: | 1801-7592 0042-773X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::033354a99c1c976c350bad2283d7b2aa https://doi.org/10.36290/vnl.2019.124 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........033354a99c1c976c350bad2283d7b2aa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18017592 0042773X |
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