Reduced antioxiadant high-density lipoprotein function in patients with acute coronary syndrome
| العنوان: | Reduced antioxiadant high-density lipoprotein function in patients with acute coronary syndrome |
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| المؤلفون: | N Pagonas, L Weiland, M Jaensch, W Dammernmann, M Christ, O Ritter, T Westhoff, T Kelesidis, B Sasko |
| المصدر: | European Heart Journal. 43 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Background High-density lipoprotein (HDL) function rather than concentration plays an important role in the pathogenesis of cardiovascular diseases associated with oxidative stress and inflammation such as coronary artery disease (CAD). In the last years, inflammation has been identified to have a pivotal role in the pathogenesis of acute coronary syndrome (ACS). Purpose The aim of the present study is to determine whether reduced antioxidant function of HDL is associated with ACS. Methods 197 patients with ACS were prospectively recruited and blood samples were taken in the first 48h after enrollment. Patients with chronic coronary syndrome CCS (n=727) and with invasively excluded CAD (no CAD, n=498) from another cohort from our group served as control patients. A validated cell-free biochemical assay was used to determine reduced HDL antioxidant function as assessed by increased HDL-lipid peroxide content (HDLox) normalized by HDL-C levels and the mean value of a pooled serum control from healthy participants (nHDLox; no units). Results Patients with ACS had significantly increased HDLox blood levels compared to patients with CCS and to patients without CAD (p Conclusions HDL peroxidation is associated with the presence of ACS independent of the presence of other traditional risk factors. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): BIOX |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::03f9495184b12e41b4613b27ef279f26 https://doi.org/10.1093/eurheartj/ehac544.1290 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........03f9495184b12e41b4613b27ef279f26 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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