Permethyl-β-Cyclodextrin Spin-Labeled with Nitronyl Nitroxide: Synthesis and EPR Study
| العنوان: | Permethyl-β-Cyclodextrin Spin-Labeled with Nitronyl Nitroxide: Synthesis and EPR Study |
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| المؤلفون: | Elena G. Bagryanskaya, V. G. Vasiliev, A. S. Medvedeva, V. V. Novokshonov, Evgeny V. Tretyakov, Matvey V. Fedin, Rodion K. Strizhakov, V. I. Ovcharenko, Olesya A. Krumkacheva |
| المصدر: | Applied Magnetic Resonance. 45:1087-1098 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Nitroxide mediated radical polymerization, Cyclodextrin, Chemistry, Stereochemistry, Ascorbic acid, Atomic and Molecular Physics, and Optics, law.invention, Crystallography, Reaction rate constant, law, Covalent bond, Electron paramagnetic resonance, Spin labeled, Dynamic equilibrium |
| الوصف: | A method for synthesis of new covalently linked spin-labeled cyclodextrin (CD) via the attachment of nitronyl nitroxide 2-(4-hydroxyphenyl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl to permethylated β-cyclodextrin is described. Electron spin echo envelope modulation (ESEEM) studies demonstrate that the new spin-labeled CD exhibits dynamic equilibrium between conformations with radical fragment capping the cavity of CD and radical fragment located outside the cavity. In solution, nitronyl nitroxide attached to CD retains its sensitivity to nitric oxide (NO), as reaction with NO leads to formation of iminonitroxide fragment evidenced by continuous-wave (CW) electron paramagnetic resonance (EPR). At the same time, CW EPR study of the reaction with ascorbic acid shows that the described binding of nitronyl nitroxide to CD does not provide higher stability of radical towards the reduction, and the corresponding rate constants are close to those obtained for free nitronyl nitroxide. Plausible explanations of these observations are discussed. |
| تدمد: | 1613-7507 0937-9347 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::057c4f5afeedfdc598c01d8ba16baa59 https://doi.org/10.1007/s00723-014-0591-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........057c4f5afeedfdc598c01d8ba16baa59 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16137507 09379347 |
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