The Effect of Corticosteroids for Acute Optic Neuritis on the Subsequent Development of Multiple Sclerosis
| العنوان: | The Effect of Corticosteroids for Acute Optic Neuritis on the Subsequent Development of Multiple Sclerosis |
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| المؤلفون: | David I. Kaufman, Jonathan D. Trobe, Roy W. Beck, Donald W. Paty, Patricia A. Cleary, Brown Ch, Mark J. Kupersmith |
| المصدر: | New England Journal of Medicine. 329:1764-1769 |
| بيانات النشر: | Massachusetts Medical Society, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Chemotherapy, medicine.medical_specialty, business.industry, medicine.drug_class, Eye disease, Multiple sclerosis, medicine.medical_treatment, General Medicine, Placebo, medicine.disease, Surgery, Prednisone, Internal medicine, medicine, Corticosteroid, Optic neuritis, business, medicine.drug, Every Six Hours |
| الوصف: | Background Optic neuritis is often the first clinical manifestation of multiple sclerosis, but little is known about the effect of corticosteroid treatment for optic neuritis on the subsequent risk of multiple sclerosis. Methods We conducted a multicenter study in which 389 patients with acute optic neuritis (and without known multiple sclerosis) were randomly assigned to receive intravenous methylprednisolone (250 mg every six hours) for 3 days followed by oral prednisone (1 mg per kilogram of body weight) for 11 days, oral prednisone (1 mg per kilogram) alone for 14 days, or placebo for 14 days. Neurologic status was assessed over a period of two to four years. The patients in the first group were hospitalized for three days; the others were treated as outpatients. Results Definite multiple sclerosis developed within the first two years in 7.5 percent of the intravenous-methylprednisolone group (134 patients), 14.7 percent of the oral-prednisone group (129 patients), and 16.7 percent of the placebo grou... |
| تدمد: | 1533-4406 0028-4793 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::05cc2c2c8558cd3711dd96eb22d713bf https://doi.org/10.1056/nejm199312093292403 |
| رقم الأكسشن: | edsair.doi...........05cc2c2c8558cd3711dd96eb22d713bf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15334406 00284793 |
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