Quantitative Analysis of the Antimicrobial Activity and Membrane-perturbation Potency of AntifoulingPara-substituted Alkylphenols
| العنوان: | Quantitative Analysis of the Antimicrobial Activity and Membrane-perturbation Potency of AntifoulingPara-substituted Alkylphenols |
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| المؤلفون: | Kimio Sugiyama, Nobuyoshi Ban, Kanzo Sakata, Naoharu Watanabe, Junko Fujiyoshi, Nobuko Murayama, Kazuo Ina, Hideo Etoh, Hajime Iwamura, Hideto Miyoshi |
| المصدر: | Bioscience, Biotechnology, and Biochemistry. 58:467-469 |
| بيانات النشر: | Oxford University Press (OUP), 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Organic Chemistry, Membrane structure, Substituent, Biological activity, Biological membrane, General Medicine, Antimicrobial, Applied Microbiology and Biotechnology, Biochemistry, Analytical Chemistry, Biofouling, chemistry.chemical_compound, Membrane, chemistry, Organic chemistry, Phenols, Molecular Biology, Biotechnology |
| الوصف: | To better understand the antifouling action of para-substituted phenolic compounds, the antimicrobial activity, which is known to be related to the antifouling activity, was examined with Trychophyton mentagrophytes. The effect of phenolic compounds on mitochondrial swelling was also investigated to elucidate their membrane-perturbation action. The variation of each activity was quantitatively analyzed by a regression analysis, using hydrophobic substituent parameter π. Each activity varied parabolically with increasing hydrophobicity of the para-substituent, the optimum π value being ca. 3.5–4.0. The introduction of a bulky substituent to the ortho position resulted in a drastic decrease in each activity. It is therefore likely that the antimicrobial activity is due to perturbation of the membrane structure. Considering the good correlation between the antifouling and antimicrobial activities of para-substituted phenols, the antifouling activity is assumed to be related to perturbation of the membrane st... |
| تدمد: | 1347-6947 0916-8451 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::05ff2e4c4c67392a2e0fb009517b6b19 https://doi.org/10.1271/bbb.58.467 |
| رقم الأكسشن: | edsair.doi...........05ff2e4c4c67392a2e0fb009517b6b19 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 13476947 09168451 |
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