IL-12, IFN-γ, and T Cell Proliferation to Measles in Immunized Infants
| العنوان: | IL-12, IFN-γ, and T Cell Proliferation to Measles in Immunized Infants |
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| المؤلفون: | Hayley A. Gans, Yvonne Maldonado, Linda L. Yasukawa, Judy Beeler, Susette Audet, Mary M. Rinki, Ross DeHovitz, Ann M. Arvin |
| المصدر: | The Journal of Immunology. 162:5569-5575 |
| بيانات النشر: | The American Association of Immunologists, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | Measles infection in infants is associated with severe complications, and secondary infections are attributed to generalized immunosuppression. Measles binding to its monocyte receptor down-regulates IL-12 which is expected to diminish Th1-like cytokine responses, including IFN-γ. Whether young infants can be immunized effectively against measles is an important public health issue. We evaluated Ag-specific IL-12, IFN-γ, and T cell responses of infants at 6 (n = 60), 9 (n = 46), or 12 mo (n = 56) of age and 29 vaccinated adults. IL-12 and IFN-γ release by PBMC stimulated with measles Ag increased significantly after measles immunization in infants. IL-12 and IFN-γ concentrations were equivalent in younger and older infants, but IL-12 concentrations were significantly lower in infants than in adults (p = 0.04). IL-12 production by monocytes was down-regulated by measles; the addition of recombinant human IL-12 enhanced IFN-γ production by PBMC stimulated with measles Ag, but infant T cells released significantly less IFN-γ than adult T cells under this condition. Of particular interest, the presence of passive Abs to measles had no effect on the specific T cell proliferation or IFN-γ production after measles stimulation. Cellular immunity to measles infection and vaccination may be limited in infants compared with adults as a result of less effective IFN-γ and IL-12 production in response to measles Ags. These effects were not exaggerated in younger infants compared with effects in infants who were immunized at 12 mo. In summary, infant T cells were primed with measles Ag despite the presence of passive Abs, but their adaptive immune responses were limited compared with those of adults. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0689ca728130ada4d53c06d63bc6ce9c https://doi.org/10.4049/jimmunol.162.9.5569 |
| رقم الأكسشن: | edsair.doi...........0689ca728130ada4d53c06d63bc6ce9c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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