Background: Polypharmacy is common and increasing among geriatric patients. Polypharmacy has been strongly associated with drug-drug interactions (DDIs). Polypharmacy and DDIs represent potential health hazards for the elderly. Aim and Objective: This study aims to analyze the polypharmacy and associated potential DDIs (pDDIs) among geriatric patients. Materials and Methods: A total of 484 geriatric (age ≥65 years) patients, who have fulfilled the selection criteria, were included in the study. Polypharmacy was assessed from prescriptions. pDDI was assessed using computer-based checks online available on the internet. Results: A total of 111 patients (22.93%) were prescribed ≥6 drugs simultaneously polypharmacy. Six patients were prescribed ≥10 drugs (hyperpolypharmacy) simultaneously. A total of 191 (39.46%) prescriptions have at least one pDDI 98 (20.24%) prescriptions, 63 (13.02%) prescriptions, and 30 (6.20%) prescriptions have 12 pDDI, 35 pDDI, and ≥6 pDDI, respectively, with total pDDIs were 578. The statistically significant association has been found between the polypharmacy and pDDI (
