CD83 + CCR7 + NK cells induced by interleukin 18 by dendritic cells promote experimental autoimmune uveitis
| العنوان: | CD83 + CCR7 + NK cells induced by interleukin 18 by dendritic cells promote experimental autoimmune uveitis |
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| المؤلفون: | Qiang Fu, Wei Lin, Yufei Sun, Xuejing Man, Jiangnan Xue, Nannan Song, Yuanbin Li, Xin Wang |
| المصدر: | Journal of Cellular and Molecular Medicine. 23:1827-1839 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, biology, Chemistry, CD69, CD3, chemical and pharmacologic phenomena, hemic and immune systems, C-C chemokine receptor type 7, Cell Biology, medicine.disease, NKG2D, eye diseases, In vitro, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, immune system diseases, 030220 oncology & carcinogenesis, Immunology, medicine, biology.protein, Molecular Medicine, Interleukin 18, Antibody, Uveitis |
| الوصف: | Natural killer (NK) cells have been reported to play a pathological role in autoimmune uveitis. However, the mechanisms regarding NK cells in uveitis and factors that affect NK-cell activation in this condition remain unclear. Here, we report that the number of CD3- NK1.1+ CD83+ CCR7+ cells is increased in the inflamed eyes within a mouse model of experimental autoimmune uveitis (EAU), and these cells express elevated levels of NKG2D, CD69 and IFN-γ. Adoptively transferring CD83+ CCR7+ NK cells aggravates EAU symptoms and increases the number of CD4+ IFN-γ+ T cells and dendritic cells (DCs) within the eye. These CD83+ CCR7+ NK cells then promote the maturation of DCs and IFN-γ expression within T cells as demonstrated in vitro. Furthermore, IL-18, as primarily secreted by DCs in the eyes, is detected to induce CD83+ CCR7+ NK cells. In EAU mice, anti-IL-18R antibody treatment also decreases retinal tissue damage, as well as the number of infiltrating CD83+ CCR7+ NK cells, T cells and DCs in the inflamed eyes and spleens of EAU mice. These results suggest that CD83+ CCR7+ NK cells, as induced by IL-18 that primarily secreted by DCs, play a critical pathological role in EAU. Anti-IL-18R antibody might serve as a potential therapeutic agent for uveitis through its capacity to inhibit CD83+ CCR7+ NK cells infiltration. |
| تدمد: | 1582-4934 1582-1838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::06ce69dfd46f4988b4ad9f1d9531d865 https://doi.org/10.1111/jcmm.14081 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........06ce69dfd46f4988b4ad9f1d9531d865 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15824934 15821838 |
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