Survival in Alzheimer’s Disease Is Shorter in Women Carrying Heterozygosity at Codon 129 of the PRNP Gene and No APOE ε4 Allele
| العنوان: | Survival in Alzheimer’s Disease Is Shorter in Women Carrying Heterozygosity at Codon 129 of the PRNP Gene and No APOE ε4 Allele |
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| المؤلفون: | Adele Acciarri, Piero Antuono, David R. Wekstein, Carlo Masullo, Anna Poleggi, Maria Giovanna Matera, Alessandra Bizzarro, Maria Puopolo, Claudia Giannattasio, Davide Seripa, Gloria Dal Forno, Alessandra Lauria, Maurizio Pocchiari |
| المصدر: | Dementia and Geriatric Cognitive Disorders. 25:354-358 |
| بيانات النشر: | S. Karger AG, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Genetics, Apolipoprotein E, Cognitive Neuroscience, Disease, Biology, medicine.disease, Loss of heterozygosity, Psychiatry and Mental health, Degenerative disease, Genotype, medicine, Prnp gene, Geriatrics and Gerontology, Allele, Alzheimer's disease |
| الوصف: | We assessed the role of the APOE genotype and prion protein polymorphism at codon 129 in predicting the clinical duration of 92 neuropathologically confirmed sporadic Alzheimer’s disease patients. Analyses of survival showed that the absence of the APOE Ε4 allele in heterozygous codon 129 PRNP carriers is a negative predictor of survival. When this subgroup of patients was stratified by sex, the effect of APOE was observed in women, but not in men. |
| تدمد: | 1421-9824 1420-8008 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::0705e5cc2244bb9ff043cacac684e42b https://doi.org/10.1159/000119730 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........0705e5cc2244bb9ff043cacac684e42b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219824 14208008 |
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