Misnotkun lóperamíðs - hægðatregða eða hjartastopp?
| العنوان: | Misnotkun lóperamíðs - hægðatregða eða hjartastopp? |
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| المؤلفون: | Magnús Haraldsson, Magnus Johannsson, Gudrun Dora Bjarnadottir, Anna Gunnarsdottir |
| المصدر: | Læknablaðið. 2018:543-548 |
| بيانات النشر: | Laeknabladid/The Icelandic Medical Journal, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Drug, medicine.medical_specialty, Loperamide, Constipation, Prescription drug, business.industry, media_common.quotation_subject, General Medicine, Cardiac dysrhythmia, Internal medicine, medicine, Over-the-counter, medicine.symptom, Medical prescription, Adverse effect, business, media_common, medicine.drug |
| الوصف: | Loperamide is a μ-opioid receptor agonist with antidiarrhoeal effects. It is considered to have a low abuse potential because of substantial first-pass metabolism and P-glycoprotein-mediated efflux at the level of the blood-brain barrier. Previous case reports have described that high dosage of loperamide can induce an opioid-like effect on the central nervous system. The most common presentation of loperamide intoxication is syncope which is caused by serious cardiac dysrhythmia and can lead to death. Therefore, it was decided to analyze whether drug prescriptions in the prescription drug database from The Directorate of Health would indicate loperamide misuse in Iceland from 2006-2017. In total 94 individuals used more than one DDD (10 mg) and 17 individuals used more than two DDD (20 mg), if taken daily over one year. These results indicate that loperamide is being used excessively but the reason for each prescription and the total amount sold over the counter is unknown. Increased surveillance and decreased availability of prescription opioids might possibly boost the usage of drugs with similar function such as loperamide. Loperamide overdose can result in serious adverse effects and thus, it is important to inform healthcare employees about such severe consequences. |
| تدمد: | 1670-4959 0023-7213 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::070bddd490f2efc01606cdbde0a775fa https://doi.org/10.17992/lbl.2018.12.207 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........070bddd490f2efc01606cdbde0a775fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16704959 00237213 |
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