Abstract 15077: Serum-transthyretin: Does it Predict Ablation Outcome in Patients With Atrial Fibrillation?
| العنوان: | Abstract 15077: Serum-transthyretin: Does it Predict Ablation Outcome in Patients With Atrial Fibrillation? |
|---|---|
| المؤلفون: | Domenico G. Della Rocca, Andrea Natale, Sanghamitra Mohanty, John Burkhardt, Bryan MacDonald, Amin Al-Ahmad, Joseph G. Gallinghouse, Chintan Trivedi, Angel Mayedo, Mohamed Bassiouny, Rodney Horton, Faiz M. Baqai, Rong Bai, Carola Gianni |
| المصدر: | Circulation. 142 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, biology, business.industry, medicine.medical_treatment, nutritional and metabolic diseases, Atrial fibrillation, medicine.disease, Ablation, Transthyretin, Physiology (medical), Internal medicine, medicine, biology.protein, Cardiology, In patient, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background: Transthyretin (TTR), a transport protein produced by liver, is closely associated with amyloidosis. Tetramers of TTR circulating in blood can dissociate to monomers that misassemble into amyloid fibrils. Although amyloidosis is a frequent finding in aged atrial fibrillation (AF) patients, the relevance of serum-TTR in AF is unknown. Objective: We evaluated if post-ablation change in serum-TTR level has any prognostic association with long-term ablation outcome in AF patients. Methods: One-hundred-forty-five patients (age: 62.8 ± 6.2years, male 69%, non-paroxysmal AF 41%, BMI : 30.8 ± 6.3) were included in this prospective study. Patients with chronic inflammatory conditions or taking anti-inflammatory drugs were excluded. All patients received pulmonary vein isolation plus isolation of left atrial posterior wall and superior vena cava. In non-paroxysmal AF, non-PV triggers identified by isoproterenol challenge were ablated. Fasting blood samples were collected at baseline and 24-hours post-ablation. Samples were tested for TTR using an automated quantitative test. Results: Mean TTR concentration was 27.94±6.5 mg/dL at baseline and 26.33±9.2 mg/dL at 24-hour post ablation (p Conclusion: Our findings demonstrated significant association of higher recurrence rate with decreased serum-TTR tetramer level at 24-hour post-ablation. |
| تدمد: | 1524-4539 0009-7322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::07c387366cae1dcb54ca79ca736597e8 https://doi.org/10.1161/circ.142.suppl_3.15077 |
| رقم الأكسشن: | edsair.doi...........07c387366cae1dcb54ca79ca736597e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244539 00097322 |
|---|