Long-term prognostic value of concomitant inflammation and malnutrition in patients undergoing valvular heart surgery
| العنوان: | Long-term prognostic value of concomitant inflammation and malnutrition in patients undergoing valvular heart surgery |
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| المؤلفون: | D Hung, Y K Tse, Q W Ren, J Y Huang, K H Yiu |
| المصدر: | European Heart Journal. 43 |
| بيانات النشر: | Oxford University Press (OUP), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
| الوصف: | Background Recent studies have shown that inflammation and malnutrition are associated with poor prognosis in valvular heart diseases. Nonetheless, the prognostic role of blood inflammatory markers and nutritional indices for risk stratification in valvular heart surgery remains unknown. Purpose This study aimed to evaluate the long-term prognostic implications of inflammatory and nutritional status in predicting survival and adverse outcomes in patients who underwent valvular heart surgery. Methods 1048 patients who underwent valvular heart surgery between 2012 and 2020 were stratified into three groups according to their inflammatory (using neutrophil-to-lymphocyte ratio [NLR]) and nutritional status (using prognostic nutritional index [PNI]) at baseline: (1) absence of inflammation and malnutrition, (2) inflammation or malnutrition alone, and (3) concomitant inflammation and malnutrition. Optimal NLR and PNI thresholds for predicting all-cause mortality were determined using receiver-operating characteristic curve analysis. The discriminatory capacity of NLR and PNI adding to EuroSCORE II was assessed with continuous net reclassification (cNRI) and integrated discrimination improvement (IDI) indices. The endpoints of interest included all-cause mortality, cardiovascular (CV) death and adverse events (defined as the composite of death and heart failure [HF] hospitalization). Results Over a median follow-up of 3.9 years (IQR: 2.0 to 6.1 years), 139 (13.3%) deaths, in which 51 (4.9%) were due to cardiovascular causes, and 109 (10.4%) HF hospitalizations occurred. Based on the optimal cutoff of NLR>4.06 (inflammation) and PNI Conclusions Concomitant inflammation and malnutrition is common and is strongly associated with mortality and HF in patients undergoing valvular heart surgery. The assessment of preoperative and postoperative inflammatory and nutritional status of patients could be useful for the prognostication of valvular surgery. Funding Acknowledgement Type of funding sources: None. |
| تدمد: | 1522-9645 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::07d56aa4759950c443aeba7fbe62db93 https://doi.org/10.1093/eurheartj/ehac544.2076 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........07d56aa4759950c443aeba7fbe62db93 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15229645 0195668X |
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