New Ru II Scaffold for Photoinduced Ligand Release with Red Light in the Photodynamic Therapy (PDT) Window
| العنوان: | New Ru II Scaffold for Photoinduced Ligand Release with Red Light in the Photodynamic Therapy (PDT) Window |
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| المؤلفون: | Kathlyn F. Al-Afyouni, Claudia Turro, Lauren M. Loftus |
| المصدر: | Chemistry – A European Journal. 24:11550-11553 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Steric effects, 010405 organic chemistry, Ligand, Chemistry, medicine.medical_treatment, Organic Chemistry, chemistry.chemical_element, Photodynamic therapy, General Chemistry, 010402 general chemistry, Photochemistry, 01 natural sciences, Catalysis, Dissociation (chemistry), 0104 chemical sciences, Ruthenium, Bipyridine, chemistry.chemical_compound, Excited state, medicine, Red light |
| الوصف: | Four new RuII complexes, [Ru(tpy)(L)(CH3 CN]+ , where tpy=2,2':6',2"-terpyridine and L represents a series of acetylacetonate-based ligands, were synthesized for enhanced photoinduced ligand release with red light, λirr =655 nm. The metal-to-ligand charge transfer, 1 MLCT, transitions of these complexes are red-shifted and exhibit quantum yields of ligand dissociation that are five- to seven-fold greater than that of [Ru(tpy)(bpy)(CH3 CN)]2+ (bpy=2,2'-bipyridine), despite the absence of additional steric distortion. This series of complexes represents a new scaffold for drug photocaging and one of the first examples of RuII photocages that can release nitriles with light in the photodynamic therapy (PDT) window required for optimal tissue penetration. |
| تدمد: | 1521-3765 0947-6539 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::08c807958f6829880963bd8148343ea9 https://doi.org/10.1002/chem.201802405 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi...........08c807958f6829880963bd8148343ea9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15213765 09476539 |
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