Ionic liquids (ILs) are salts composed of a large organic or inorganic cation in which an alkyl chain is replaced or inorganic or organic anions. Because of unique ILs properties, they have attracted significant attention from ecologists, medical scientists, and biochemists. Controlling the toxicity of ionic liquids by combining them with various substances is another important factor that has been investigated to make them better and easier to use in pharmaceutical applications. Therefore, the novel design and control of the molecular structure of these compounds can assist their antibacterial applications.