Camrelizumab as adjuvant therapy in urothelial carcinomas after radical surgery in people living with HIV
| العنوان: | Camrelizumab as adjuvant therapy in urothelial carcinomas after radical surgery in people living with HIV |
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| المؤلفون: | Menghua Wu, Yuefeng Pang, Xin Zheng, Jimao Zhao |
| المصدر: | International Journal of STD & AIDS. :095646242311731 |
| بيانات النشر: | SAGE Publications, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Infectious Diseases, Public Health, Environmental and Occupational Health, Pharmacology (medical), Dermatology |
| الوصف: | Background Immune checkpoint inhibitors (ICIs) are effective strategies for multiple cancers and may be safe in people living with HIV (PLWH). Camrelizumab is a monoclonal antibody against PD-1 activating T cells against tumor cells. Evidence of camrelizumab’s safety and activity in PLWH with urothelial carcinoma (UC) is lacking. Here, findings in a cohort of people living with HIV with advanced or metastatic urothelial carcinoma are presented. Methods Patients who had locally advanced or metastatic disease after radical surgery were given camrelizumab (200 mg intravenously every 3 weeks). The primary endpoint was objective response per Response Evaluation Criteria in Solid Tumors version 1.1. The second endpoint was adverse events after treatment. Results In total, nine patients were included in this study with a median follow-up of 6.2 months (4.1–20.5). The objective response rate achieved 55%. Tumor response comprised 2 (22%) complete responses and 3 (33%) partial responses. The median of progression-free survival was 6.2 months (95% CI, 9.83–20.63). Only two grade 3 adverse reactions were reported (no toxic deaths or immune-related deaths). Conclusion Camrelizumab showed potent antitumor activity and acceptable safety in PLWH with advanced or metastatic urothelial carcinoma. |
| تدمد: | 1758-1052 0956-4624 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_________::09353b6dbd3122abd1ba48341a20042a https://doi.org/10.1177/09564624231173179 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi...........09353b6dbd3122abd1ba48341a20042a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17581052 09564624 |
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